Ozoralizumab

Vitamins support normal growth, development, and cell functions. All B vitamins help convert carbohydrates into a source of energy (glucose), and assist in the formation of red blood cells.

B vitamins are important for cell metabolism. Vitamins B6 (pyridoxine), B9 (folic acid), and B12 (cobalamin) can also reduce levels of the amino acid homocysteine. Homocysteine levels are commonly high in people over 65 and are linked to strokes, coronary artery disease, and dementia.

It is thought that B vitamins may affect depression in these ways:

• Some people with depression have been found to have low levels of folate (B9).
• Vitamin B6, folate (B9) and B12 can change levels of brain chemicals that affect mood (such as serotonin and norepinephrine).
• SAMe is a natural chemical in the body that may help depression. Folate (B9) and vitamin B12 are involved in the production of SAMe.
• Vitamin B12 helps maintain the insulation around brain cells. The insulation helps brain cells to communicate.

There is very little scientific evidence on vitamin B6 and B12 for the treatment of depression. More studies of better quality are needed. Short-term use of vitamins by themselves do not seem to help reduce depression symptoms. Some studies have found that taking folate (B9) alongside anti-depressant medication can be helpful, and one study found that long-term use of B vitamins reduced the risk of relapse for people who had recovered from depression.

Allergic sensitization has been reported following both oral and parenteral administration of folic acid. Paresthesia, somnolence, nausea and headache have been reported with pyridoxine hydrochlloride. Mild transient diarrhea, polycythemia vera, itching, transitory exanthema, and the feeling of swelling of the entire body has been associated with cyanocobalamin.

B vitamin supplements will not improve cognition in most adults, but it may protect from cognitive decline in some high risk groups. High homocysteine levels have been consistently associated with dementia risk, and a randomized controlled trial suggests that B vitamin supplementation slows cognitive decline in select groups, including people with mild cognitive impairment and high baseline homocysteine levels. A large meta-analysis did show that while B vitamins lowered homocysteine levels, they did not affect cognitive function. But, the results were questioned due to the lack of people experiencing cognitive decline in the trials and other factors.

Ozoralizumab should be taken early in the day, preferably with your first meal, as they help the body produce energy from food and taking them later in the day can interfere with your sleep.

Usual adult dose is one to two tablets daily or as directed by a physician.