P Plus
P Plus Uses, Dosage, Side Effects, Food Interaction and all others data.
P Plus induces electrochemical abnormalities across the membranes of excitable cells, leading to sensory hyperexcitability, in coordination and prostration. P Plus is rapidly metabolized in mammals by ester hydrolysis to inactive metabolites which are excreted primarily in the urine. The principal metabolites of P Plus are detectable in the urine within hours of a whole body application of the cream to healthy volunteers or scabies patients. The highest levels of excretion are detectable within the first 48 hours, but very low levels of metabolites are still detectable in the urine of some individuals 28 days after treatment.
P Plus, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.
| Trade Name | P Plus |
| Generic | Permethrin |
| Permethrin Other Names | Permethrin |
| Type | Cream, Soap, Tablet, Capsule |
| Formula | C21H20Cl2O3 |
| Weight | Average: 391.288 Monoisotopic: 390.07894992 |
| Groups | Approved, Investigational |
| Therapeutic Class | Parasiticidal preparations |
| Manufacturer | Cian Healthcare, Logos Pharmaceuticals, Vilin Bio Med Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
P Plus is used for the treatment of scabies.
P Plus is also used to associated treatment for these conditions: Head Lice Infestation, Norwegian scabies, Scabies, Lice of the pubic area
How P Plus works
P Plus acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance.
Dosage
P Plus dosage
For 15 gm Tube:
- Adults and children (over 12 years): Use two full tube
- Children aged 6-12 years: Use a full tube
- Children aged 1-5 years: Use up to 1/2 of a tube
- Children aged 2 months to 1 year: Use up to 1/4 of a tube
For 30 gm Tube:
- Adults and children (over 12 years): Use a full tube
- Children aged 6-12 years: Use up to 1/2 of a tube
- Children aged 1-5 years: Use up to 1/4 of a tube
- Children aged 2 months to 1 year: Use up to 1/8 of a tube
- Patients of >2 months of age can use the dermal cream.
- Cream should be applied to clean, dry skin. If the body is hot due to warm bath or any other reason, skin should be allowed to cool.
- It should be applied to the whole body excluding head.
- The whole body should be washed thoroughly 8-12 hours after treatment.
- Adults and children above 12 years will use a 30 g tube as a single dose.
- If necessary maximum two tubes (60 gm) can be used as a single dose.
- The cream should not be applied to the vicinity of mouth and areas close to the eyes.
Side Effects
In scabies patients, skin discomfort, usually described as burning, stinging or tingling occurs in a few individuals soon after the cream is applied. Other transient signs and symptoms of irritation including erythema, edema, eczema, rash and pruritus which may follow the treatment of scabies with P Plus are generally considered to be the part of the natural history of scabies. In patients treated for scabies, itching may persist for up to 4 weeks post-treatment. This is generally regarded as due to an allergic reaction to the dead mites under the skin and is not necessarily indicative of a treatment failure.
Toxicity
Oral, rat LD50: 430 - 4000 mg/kg; skin, rabbit LD50: 2000 mg/kg.
Precaution
P Plus is not an eye-irritant, but the cream itself may cause marked irritation. Nursing staff who routinely apply P Plus, may wear gloves to avoid any possible irritation to the hands.
Interaction
The treatment of eczematous-like reactions with corticosteroids should be withheld prior to treatment with P Plus, as there is a risk of exacerbating the scabies infestation by reducing the immune response to the mite.
Food Interaction
No interactions found.Elimination Route
Poorly absorbed through the skin.
Elimination Route
P Plus is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.
Pregnancy & Breastfeeding use
There are limited data on the use of P Plus in pregnancy which provide no indication of any risk to the foetus. Furthermore, the amount of P Plus absorbed systemically following a whole body application is extremely low. The negative mutagenicity tests and the very low mammalian toxicity would suggest that any risk to the foetus following treatment with P Plus is minimal. Inspite of these, P Plus is suggested not to useduring pregnancy.
It is not known whether P Plus is excreted in human breast milk. So, it should not be used in nursing mothers.
Contraindication
P Plus is contraindicated in subjects with known hypersensitivity to the product, its components, other pyrethroids or pyrethrins.
Acute Overdose
There are no reports of overdosage with P Plus. It is possible that excessive application of P Plus might result in localized adverse reactions or more severe skin reactions.
Storage Condition
Store at a cool and dry place. Protect from light. Do not freeze.
Innovators Monograph
You find simplified version here P Plus
P Plus contains Permethrin see full prescribing information from innovator P Plus Monograph, P Plus MSDS, P Plus FDA label
FAQ
What is P Plus used for?
P Plus is used to treat scabies and lice. It is applied to the skin as a cream or lotion. As an insecticide, P Plus can be sprayed onto clothing or mosquito nets to kill the insects that touch them.P Plus topical may also be used for other purposes not listed in this medication guide.
How safe is P Plus?
P Plus is considered safe for topical use in adults and children over the age of two months.
How does P Plus work?
P Plus works by paralyzing and killing the mites and their eggs.
What are the common side effects of P Plus?
- Mild and transient burning and stinging.
- Itching.
- Skin redness.
- Skin swelling.
- Skin rash.
- Numbness or tingling where the medicine was applied.
- Scabies symptoms may temporarily worsen after treatment.
Common side effects of P Plus are include :
Is P Plus safe during pregnancy?
Animal studies have revealed no evidence of impaired fertility or harm to the fetus. There are no controlled data in human pregnancy. P Plus topical is only recommended for use during pregnancy when benefit outweighs risk.
Is P Plus safe during breastfeeding?
P Plus is generally considered safe for children and adults of all ages, including women who are breastfeeding.
Can I drink alcohol with P Plus?
After using P Plus, you should wash all clothing, sheets, and towels you used in hot water. You should also clean all showers, toilets, and bathtubs with rubbing alcohol to kill remaining parasites.
Does alcohol affect P Plus?
After using P Plus, you should wash all clothing, sheets, and towels you used in hot water. You should also clean all showers, toilets, and bathtubs with rubbing alcohol to kill remaining parasites.
How long does it take P Plus to work?
The dermal cream should be applied for 8-12 hours, while users are instructed to apply the cream rinse for 10 minutes only. Ten minutes is not long enough to enable the P Plus to penetrate burrows or skin, a factor that was relevant in one case reported here.
How long does P Plus last?
At the concentration level delivered in the aerosol, non-aerosol pump sprays and soak systems, an application lasts for six weeks and through six washings. P Plus breaks down through exposure to air and sunlight.
Does P Plus stop itching?
Even if P Plus kills all the scabies, the dead mites can still make you itch for up to 4 weeks after treatment. Ask your doctor about other medications that may be used to soothe the itching.
How often can I take P Plus?
Use two applications of P Plus cream, seven days apart. Your whole body must be treated with the cream. Leave each application on for 8-12 hours, then wash the cream off with soap and water.
Can I overdose on P Plus ?
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.
Who should not take P Plus?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What happens if I miss a dose?
Since P Plus topical is usually needed only once, you are not likely to be on a dosing schedule. Wait at least 7 days before using a second application.
Do I put P Plus on vagina?
Apply P Plus topical to all pubic hair and any surrounding hairs on the thighs and around the anus. Leave the medicine on for 10 minutes. Then work into a lather and rinse thoroughly with warm water.
Is it safe to use P Plus everyday?
Topical P Plus, applied once daily, is considered as the most effective treatment in scabies.
