PA-1050040
PA-1050040 Uses, Dosage, Side Effects, Food Interaction and all others data.
PA1050040, a second generation HIV-1 maturation inhibitor, is a chemical analog of Bevirimat (BVM). It inhibits virus replication by the same mechanism of action as BVM.
| Trade Name | PA-1050040 |
| Generic | PA-1050040 |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in HIV infection.
How PA-1050040 works
Like protease inhibitors, PA-1050040 and other maturation inhibitors interfere with protease processing of newly translated HIV polyprotein precursor, called gag. This molecule contains a number of HIV proteins in a single polypeptide which is then cleaved by the enzyme protease to produce functional structural proteins. However, unlike the protease inhibitors, PA-1050040 binds the gag protein, not protease. Once bound to gag, PA-1050040 prevents a critical cleavage at a site called the capsid-SP1 junction. The resulting virus particles lack functional capsid protein and have structural defects, rendering them incapable of infecting other cells. For reasons not entirely understood, protease inhibitor-resistant HIV-1 was hypersensitive to PA-1050040 in vitro.
Innovators Monograph
You find simplified version here PA-1050040
