PA MAb
PA MAb Uses, Dosage, Side Effects, Food Interaction and all others data.
PA MAb is a human IgG1λ monoclonal antibody that binds the protective antigen (PA) component of B. anthracis toxin. PA MAb has a molecular weight of approximately 146 kilodaltons. PA MAb is produced by recombinant DNA technology in a murine cell expression system. FDA approved on December 14, 2012.
| Trade Name | PA MAb |
| Generic | Raxibacumab |
| Raxibacumab Other Names | PA mAb, Raxibacumab |
| Type | |
| Formula | C6320H9794N1702O1998S42 |
| Weight | 142844.5367 Da |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
PA MAb is a monoclonal antibody used in conjunction with an antibacterial regimen to treat patients with inhalational anthrax caused by Bacillus anthracis and for prophylaxis of inhalational anthrax when appropriate.
PA MAb is indicated for the treatment of adult and pediatric patients with inhalational anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs, and for prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate.
PA MAb is also used to associated treatment for these conditions: Inhaled anthrax caused by Bacillus anthracis
How PA MAb works
PA MAb is a monoclonal antibody that binds free PA with an affinity equilibrium dissociation constant (Kd) of 2.78 ± 0.9 nM. PA MAb inhibits the binding of PA to its cellular receptors, preventing the intracellular entry of the anthrax lethal factor and edema factor, the enzymatic toxin components responsible for the pathogenic effects of anthrax toxin. It does not have direct antibacterial activity.
Toxicity
The most frequently reported adverse reactions were rash, pain in extremity, pruritus, and somnolence.
Food Interaction
No interactions found.Volume of Distribution
Steady state volume of distribution exceeded plasma volume. This suggests that there is some distribution into the tissues.
Elimination Route
PA MAb does not cross the blood-brain-barrier. When a single IV dose of 40 mg/kg was administered to healthy, male and female human subjects, the pharmacokinetic parameters are as follows: Cmax = 1020.3 ± 140.6 mcg/mL; AUCinf = 15845.8 ± 4333.5 mcg·day/mL. Bioavailability is also dependent on site of injection. When administered to the vastus lateralis, the bioavailability is 71-85%. When administered to the gluteus maximus, the bioavailability is 50-54%.
Half Life
Mean terminal elimination half-lives of raxibacumab are as follows: IM dose = 15-19 days; IV dose = 16-19 days
Clearance
Clearance values were much smaller than the glomerular filtration rate indicating that there is virtually no renal clearance of raxibacumab.
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