Palifermin

Palifermin Uses, Dosage, Side Effects, Food Interaction and all others data.

Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli.

Palifermin was granted FDA approval on 15 December 2004.

Used in the prevention or treatment of oral mucoscitis (mouth ulcers arising from chemotherapy), Kepivance binds to the human keratinocyte growth factor (KGF) receptor on buccal cell surfaces. Kepivance acts as both a cell growth and survival factor by stimulating epithelial cell proliferation, differentiation, and migration around the tongue and mouth. The KGF receptor is found on many tissues particularly around the tongue, esophagus, salivary gland and other gastro-intestinal tract organs.

Trade Name Palifermin
Availability Prescription only
Generic Palifermin
Palifermin Other Names 24-163 fibroblast growth factor 7 (human), Palifermin, Palifermina
Related Drugs chlorhexidine topical, Peridex, sodium hyaluronate topical, Biotene Mouthwash, XyliMelts
Weight 6.25mg,
Type Intravenous Powder For Injection, Intravenous
Formula C721H1142N202O204S9
Weight 16192.7 Da
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Palifermin
Palifermin

Uses

Palifermin is a form of recombinant human keratinocyte growth factor used to prevent and treat oral mucositis following radiation or chemotherapy.

For treatment of oral mucositis associated with chemotherapy and radiation therapy.

Palifermin is also used to associated treatment for these conditions: Oral Mucositis

How Palifermin works

Palifermin has been shown to protect oral and intestinal epithelia from the effects of radiation and chemotherapy, though the exact mechanism is not well understood. As a recombinant keratinocyte growth factor (KGF), palifermin may promote cell proliferation, reducing the severity of oral mucositis in patients in the relevant treatment groups. Agonism of fibroblast growth factor 2 may be predominantly responsible for this effect. The endogenous form if palifermin is expressed in the kidney of rats.

Food Interaction

No interactions found.

Half Life

Elimination half-life: 4.5 hours (range: 3.3-5.7 hours)

Innovators Monograph

You find simplified version here Palifermin

*** Taking medicines without doctor's advice can cause long-term problems.
Share