Palmitoyloleoyl-phosphatidylglycerol

Palmitoyloleoyl-phosphatidylglycerol Uses, Dosage, Side Effects, Food Interaction and all others data.

Palmitoyloleoyl-phosphatidylglycerol was a component of Surfaxin, discontinued in 2017, which acted as a surfactant [FDA Label]. The product was meant to compensate for alveolar surfactant deficiency and reduce to likelihood of alveolar collapse leading to acute respiratory collapse.

Palmitoyloleoyl-phosphatidylglycerol is a replacement surfactant which prevents alveolar collapse when administered intratracheally.

Palmitoyloleoyl-phosphatidylglycerol
Uses
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Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
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Trade Name	Palmitoyloleoyl-phosphatidylglycerol
Generic	1-Palmitoyl-2-oleoyl-sn-glycero-3-(phospho-rac-(1-glycerol))
1-Palmitoyl-2-oleoyl-sn-glycero-3-(phospho-rac-(1-glycerol)) Other Names	1-Palmitoyl-2-oleoyl-sn-glycero-3-(phospho-rac-(1-glycerol)), Palmitoyloleoyl-phosphatidylglycerol, PG(16:0/18:1), POPG
Type
Formula	C₄₀H₇₇O₁₀P
Weight	Average: 749.02 Monoisotopic: 748.525435677
Groups	Approved, Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Palmitoyloleoyl-phosphatidylglycerol is a synthetic lung surfactant used to treat infant respiratory distress syndrome.

Palmitoyloleoyl-phosphatidylglycerol was a component of Surfaxin which was indicated for the prevention of respiratory distress syndrome in premature infants.

How Palmitoyloleoyl-phosphatidylglycerol works

Palmitoyloleoyl-phosphatidylglycerol reduces interfacial tension at the air/water interfaces in the alveoli [FDA Label]. This prevents the tension from pulling the alveolar membranes inwards which would collapse them and lead to respiratory distress.