Paludrine

Paludrine Uses, Dosage, Side Effects, Food Interaction and all others data.

Paludrine is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.

Paludrine is a biguanide derivative that is converted to an active metabolite called cycloguanil. It exerts its antimalarial action by inhibiting parasitic dihydrofolate reductase enzyme. It has causal prophylactic and suppressive activity against P. falciparum and cures the acute infection. It is also effective in suppressing the clinical attacks of vivax malaria. However it is slower compared to 4-aminoquinolines.

Paludrine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Paludrine
Availability	Unknown
Generic	Proguanil
Proguanil Other Names	Chlorguanide, Chloroguanide, Proguanil, Proguanile, Proguanilo, Proguanilum
Weight	100mg,
Type	Tablet
Formula	C₁₁H₁₆ClN₅
Weight	Average: 253.731 Monoisotopic: 253.109423244
Protein binding	Approximately 75%
Groups	Approved
Therapeutic Class
Manufacturer	Alliance Pharmaceuticals, Takeda Gmbh
Available Country	United Kingdom, Netherlands, Portugal, United Kindgom, Nigeria,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Paludrine is a medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria.

For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.

Paludrine is also used to associated treatment for these conditions: Malaria caused by Plasmodium falciparum, Acute, uncomplicated Malaria caused by plasmodium falciparum

How Paludrine works

Paludrine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.