Panretin Gel

Panretin Gel Uses, Dosage, Side Effects, Food Interaction and all others data.

An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute).

Panretin Gel (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. Panretin Gel inhibits the growth of Kaposi's sarcoma (KS) cells in vitro.

Trade Name Panretin Gel
Generic Alitretinoin
Alitretinoin Other Names 9-cis-retinoic acid, 9-cis-Tretinoin, 9(Z)-Retinoic acid, Alitretinoin, Alitretinoína, Alitrétinoïne, Alitretinoinum
Type
Formula C20H28O2
Weight Average: 300.4351
Monoisotopic: 300.20893014
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country Spain
Last Updated: September 19, 2023 at 7:00 am
Panretin Gel
Panretin Gel

Uses

Panretin Gel is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.

For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.

Panretin Gel is also used to associated treatment for these conditions: Chronic Eczema of the hand, Cutaneous lesions, Refractory Eczema of the hand, Severe Eczema of the hand

How Panretin Gel works

Panretin Gel binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.

Food Interaction

  • Take at the same time every day.
  • Take with food. Food increases the bioavailability of alitretinoin capsules.

Innovators Monograph

You find simplified version here Panretin Gel

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000012
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http://classyfire.wishartlab.com/tax_nodes/C0003544
http://classyfire.wishartlab.com/tax_nodes/C0000339
http://classyfire.wishartlab.com/tax_nodes/C0001137
http://classyfire.wishartlab.com/tax_nodes/C0001205
http://classyfire.wishartlab.com/tax_nodes/C0003940
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http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMPR01090022
http://www.hmdb.ca/metabolites/HMDB0002369
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https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=81864
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http://www.rxlist.com/cgi/generic2/alitre.htm
https://www.drugs.com/cdi/alitretinoin.html
https://en.wikipedia.org/wiki/Alitretinoin
*** Taking medicines without doctor's advice can cause long-term problems.
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