Paracol

Paracol Uses, Dosage, Side Effects, Food Interaction and all others data.

Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes .

Calcium phosphate reacts with acid in the stomach to raise the pH . In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth . As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.

Sodium iodide is a water-soluble ionic compound with a crystal lattice. Sodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition but is more commonly used in veterinary medicine. Radiolabelled compound, Iodide I-131, is used as a diagnostic tool to evaluate thyroid function and morphology.

When intravenously administered for total parental nutrition, sodium iodide prevents the depletion of endogenous stores of iodine and subsequent deficiency symptoms .

Paracol
Uses
Dosage
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Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Interaction With other Medicine
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Trade Name	Paracol
Generic	Calcium Phosphate + Sodium Iodide
Weight	1%w/v
Type	Eye Drops
Therapeutic Class
Manufacturer	Biomedica International
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Calcium Phosphate is a compound used in supplements and antacids.

For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste .

Sodium iodide is a supplement used in total parenteral nutrition.

Indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN) .

Paracol is also used to associated treatment for these conditions: Calcium Deficiency, Calcium and Vitamin D Deficiencies, Phosphate Deficiency, Dental CareAbscesses, Bleeding of the Vitreal Body, Clouding of the Lenses, Vitreous opacities, Wounds, Total parenteral nutrition therapy

How Paracol works

The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH) . Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.

Toxicity

Acute oral LD50 is 4340 mg/kg in rat and 1000 mg/kg in mouse . Chronic iodide overdoses may result in iodism, which is commonly characterized by salivation, coryza, sneezing, conjunctivitis, headache, fever, laryngitis, bronchitis, stomatitis, parotitis and oedema of the glottis . Up to 10g of sodium iodide has been administered intravenously without any signs of toxicity .