Parametadione

Parametadione Uses, Dosage, Side Effects, Food Interaction and all others data.

Parametadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.

Parametadione is an oxazolidinedione anticonvulsant similar to trimethadione that acts on the central nervous system (CNS) to reduce the number of absence seizures (often seen in epileptics). Absence seizures involve an interruption to consciousness where the person experiencing the seizure seems to become vacant and unresponsive for a short period of time (usually up to 30 seconds). Parametadione acts on thalamic neurons in the thalamic reticular nucleus (which studies have shown to be associated with absence seizures, von Krosigk et al., 1993).

Trade Name Parametadione
Availability Discontinued
Generic Paramethadione
Paramethadione Other Names Parametadiona, Parametadione, Paramethadione, Paramethadionum
Type
Formula C7H11NO3
Weight Average: 157.1671
Monoisotopic: 157.073893223
Protein binding

Not significant

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Parametadione
Parametadione

Uses

Used for the control of absence (petit mal) seizures that are refractory to treatment with other medications.

How Parametadione works

Dione anticonvulsants such as paramethadione reduce T-type calcium currents in thalamic neurons (including thalamic relay neurons). This inhibits corticothalamic transmission and raises the threshold for repetitive activity in the thalamus. This results in a dampening of the abnormal thalamocortical rhythmicity proposed to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram (EEG) during absence seizures.

Toxicity

Symptoms of overdose include clumsiness or unsteadiness, coma, severe dizziness, severe drowsiness, severe nausea, and problems with vision.

Food Interaction

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Elimination Route

Rapid via the digestive tract.

Half Life

12 to 24 hours (however the half-life for the active metabolite is not known)

Innovators Monograph

You find simplified version here Parametadione

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0002491
http://classyfire.wishartlab.com/tax_nodes/C0000108
http://classyfire.wishartlab.com/tax_nodes/C0000197
http://classyfire.wishartlab.com/tax_nodes/C0003033
http://classyfire.wishartlab.com/tax_nodes/C0001162
http://classyfire.wishartlab.com/tax_nodes/C0000364
http://classyfire.wishartlab.com/tax_nodes/C0004140
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:7921
http://www.hmdb.ca/metabolites/HMDB0014755
http://www.genome.jp/dbget-bin/www_bget?drug:D00495
http://www.genome.jp/dbget-bin/www_bget?cpd:C07411
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=8280
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509173
https://www.chemspider.com/Chemical-Structure.7979.html
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=32894
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=7921
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1100
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001266
http://www.pharmgkb.org/drug/PA164748880
https://www.drugs.com/mtm/paramethadione.html
https://en.wikipedia.org/wiki/Paramethadione
*** Taking medicines without doctor's advice can cause long-term problems.
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