Parix Mf Oral
Parix Mf Oral Uses, Dosage, Side Effects, Food Interaction and all others data.
Parix Mf Oral, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties with minor anti-inflammatory activity.
Parix Mf Oral, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). It exhibits anti-inflammatory, analgesic, and antipyretic activities. Similar to other NSAIDs, mefenamic acid inhibits prostaglandin synthetase.
| Trade Name | Parix Mf Oral |
| Generic | Mefenamic acid |
| Mefenamic acid Other Names | Acide méfénamique, ácido mefenámico, Acidum mefenamicum, Mefenamic acid, Mefenaminsäure |
| Type | Syrup |
| Formula | C15H15NO2 |
| Weight | Average: 241.2851 Monoisotopic: 241.110278729 |
| Protein binding | 90% |
| Groups | Approved |
| Therapeutic Class | Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs) |
| Manufacturer | Active Healthcare |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Parix Mf Oral is used in mild to moderate pain including headache, dental pain, postoperative and postpartum pain, dysmenorrhoea, menorrhagia, in musculoskeletal and joint disorders such as osteoarthritis and rheumatoid arthritis; and in children with fever and juvenile idiopathic arthritis.
Parix Mf Oral is also used to associated treatment for these conditions: Mild pain, Primary Dysmenorrhoea, Gastrointestinal cramps, Moderate Pain
How Parix Mf Oral works
Parix Mf Oral binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
Dosage
Parix Mf Oral dosage
As with other NSAIDs, the lowest dose should be sought for each patient. Therefore, after observing the response to initial therapy with Parix Mf Oral, the dose and frequency should be adjusted to suit an individual patient's needs.Administration is by the oral route, preferably with food.
- Adult: A 500 mg dose should be given to adults up to three times (1.5 g total) per day.
- Infants over 6 months: 25 mg/kg of body weight daily in divided doses for not longer than 7 days.
Side Effects
In patients taking Parix Mf Oral or other NSAIDs, the most frequently reported adverse experiences include : abdominal pain, constipation, diarrhoea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers, vomiting, abnormal renal function, anaemia, dizziness, oedema, elevated liver enzymes, headache, increased bleeding time, pruritus, rash and tinnitus.
Toxicity
Oral, rat LD50: 740 mg/kg. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.
Precaution
NSAIDs should be prescribed with extreme caution in those with a prior history of ulcer disease or gastrointestinal bleeding. To minimise the potential risk for an adverse GI event, the lowest effective dose should be used for the shortest possible duration. In cases with pre-existing advanced kidney disease, treatment with Parix Mf Oral is not recommended.
Interaction
Concomitant use with CYP2C9 isoenzyme inhibitors may alter safety and efficacy of mefenamic acid. May enhance methotrexate toxicity. Reduced BP response to ACE inhibitors or angiotensin II receptor antagonists. Increased risk of serious GI events with aspirin. May reduce the natriuretic effects of furosemide or thiazide diuretics. Reduced renal lithium clearance and elevated plasma lithium levels. May enhance anticoagulant effect of warfarin.
Food Interaction
- Avoid alcohol.
- Take with food.
Volume of Distribution
- 1.06 L/kg [Normal Healthy Adults (18-45 yr)]
Elimination Route
Parix Mf Oral is rapidly absorbed after oral administration.
Half Life
2 hours
Clearance
- Oral cl=21.23 L/hr [Healthy adults (18-45 yrs)]
Elimination Route
The fecal route of elimination accounts for up to 20% of the dose, mainly in the form of unconjugated 3-carboxymefenamic acid.3 The elimination half-life of mefenamic acid is approximately two hours. Parix Mf Oral, its metabolites and conjugates are primarily excreted by the kidneys. Both renal and hepatic excretion are significant pathways of elimination.
Pregnancy & Breastfeeding use
Pregnancy: In late pregnancy, as with other NSAIDs, Parix Mf Oral should be avoided because it may cause premature closure of the ductus arteriosus. In general there are no adequate and well controlled studies in pregnant women. Parix Mf Oral should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Rated as Pregnancy Category C.
Lactation: Trace amounts of Parix Mf Oral may be present in breast milk. Taking into account the importance of the drug to the mother , decision should be made whether to discontinue nursing or to discontinue the drug.
Contraindication
Parix Mf Oral is contraindicated in patients with known hypersensitivity to Me Parix Mf Oral acid. Parix Mf Oral should not be given to patients who have experienced asthma, urticaria, or allergic type reactions after taking aspirin or other NSAIDs. Rarely fatal, anaphylactic like reactions to NSAIDs have been reported in such patients. Parix Mf Oral is contraindicated in patients with active ulceration or chronic inflammation of upper gastrointestinal tract and should not be used in patients with preexisting renal disease.
Acute Overdose
Symptoms: Headache, nausea, vomiting, epigastric pain, GI bleeding. Rarely, diarrhoea, disorientation, excitation, coma, drowsiness, tinnitus, fainting, and occasionally convulsions.
Management: Symptomatic and supportive treatment. In acute overdosage, empty the stomach immediately by inducing emesis or by gastric lavage followed by admin of activated charcoal.
Storage Condition
Store between 20-25° C.
Innovators Monograph
You find simplified version here Parix Mf Oral
Parix Mf Oral contains Mefenamic acid see full prescribing information from innovator Parix Mf Oral Monograph, Parix Mf Oral MSDS, Parix Mf Oral FDA label
FAQ
What is Parix Mf Oral used for?
Parix Mf Oral is used short-term to treat mild to moderate pain in adults and children who are at least 14 years old.
How safe is Parix Mf Oral?
Parix Mf Oral may increase your risk of heart problems, including heart attack, stroke, heart failure, or blood clot. These conditions can be fatal. Your risk may increase if you already have heart disease or have taken the medication for a long period of time or at high doses.
How does Parix Mf Oral work?
Parix Mf Oral works by stopping the body's production of a substance that causes pain, fever, and inflammation.
What are the common side effects of Parix Mf Oral?
Common side effects of Parix Mf Oral are include:
- diarrhea.
- constipation.
- gas or bloating.
- headache.
- dizziness.
- nervousness.
- ringing in the ears
Is Parix Mf Oral safe during pregnancy?
Use of Parix Mf Oral during pregnancy is not advised unless prescribed by a doctor, especially if you are 30 or more weeks pregnant.
Is Parix Mf Oral safe during breastfeeding?
Parix Mf Oral passes into breast milk and is not recommended for use while breastfeeding.
Can I drink alcohol with Parix Mf Oral?
Do not drink alcohol while taking Parix Mf Oral. Alcohol can increase your risk of stomach bleeding caused by Parix Mf Oral. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines.
Can I drive after taking Parix Mf Oral?
Parix Mf Oral Tablets may cause drowsiness, fatigue, dizziness or may affect your vision. If you experience any of these symptoms, you should not drive or operate machinery, or perform any tasks which may require you to be alert.
When should be taken of Parix Mf Oral?
Parix Mf Oral is usually taken with food every 6 hours as needed for up to 1 week.
Is it safe to take Parix Mf Oral?
Parix Mf Oral should not be used for longer than 7 days.
How many times can I take Parix Mf Oral?
Parix Mf Oral take 250 mg every six hours as needed. You shouldn't take Parix Mf Oral for longer than three days.
How long does Parix Mf Oral take to work?
If you wait until the symptoms have worsened,Parix Mf Oral may not work as well. If you are using Parix Mf Oral for painful periods, take your first dose as soon as your period starts or pain begins. Usually, you will only need to take it for the first 2 to 3 days of your period.
How long does it take for Parix Mf Oral to kick in?
Parix Mf Oral takes between 2 - 4 hours to kick in and start easing your period pain. Each 500mg dose of Parix Mf Oral kills pain for up to 8 hours, so you may need to take it two or three times a day for all-day relief.
Can I take Parix Mf Oral for a long time?
Parix Mf Oral should not be used for longer than 7 days. Follow your doctor's dosing instructions very carefully. If you use Parix Mf Oral long-term, you may need frequent medical tests.Parix Mf Oral can cause unusual results with certain medical tests.
Who should not take Parix Mf Oral?
Parix Mf Oral can increase your risk of fatal heart attack or stroke. Do not use Parix Mf Oral just before or after heart bypass surgery .Parix Mf Oral may also cause stomach or intestinal bleeding, which can be fatal.
What happens if I miss a dose on Parix Mf Oral?
Take Parix Mf Oral as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happen if I take too much Parix Mf Oral?
If you take too much If you take too much Parix Mf Oral, you may experience: drowsiness, nausea,vomiting.
When can I stop taking Parix Mf Oral?
If you experience any of the following symptoms, stop taking Parix Mf Oral and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.
Can Parix Mf Oral affects my heart ?
Parix Mf Oral can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease.
