Paromycin
Paromycin Uses, Dosage, Side Effects, Food Interaction and all others data.
An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Paromycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.
Trade Name | Paromycin |
Availability | Prescription only |
Generic | Paromomycin |
Paromomycin Other Names | Aminosidin, Aminosidine, Catenulin, Crestomycin, Estomycin, Hydroxymycin, Monomycin A, Neomycin E, Paromomicina, Paromomycin, Paromomycin I, Paromomycine, Paromomycinum, Paucimycin, Paucimycinum, Zygomycin A1 |
Related Drugs | doxycycline, metronidazole, Flagyl, albendazole, neomycin, Vibramycin, tinidazole, nitazoxanide, praziquantel, niclosamide |
Weight | 250mg |
Type | Oral capsule |
Formula | C23H45N5O14 |
Weight | Average: 615.6285 Monoisotopic: 615.296301173 |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | United States |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Paromycin is an aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma.
For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
Paromycin is also used to associated treatment for these conditions: Dientamoeba fragilis infection, Hepatic coma, Acute Intestinal amebiasis, Chronic Intestinal amebiasis
How Paromycin works
Paromycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.
Food Interaction
- Take with food.
Paromycin Drug Interaction
Unknown: lactobacillus acidophilus, lactobacillus acidophilus, nitazoxanide, nitazoxanide, amoxicillin / clavulanate, amoxicillin / clavulanate, dicyclomine, dicyclomine, glucose, glucose, amitriptyline, amitriptyline, lamivudine, lamivudine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, crofelemer, crofelemer, enfuvirtide, enfuvirtide
Paromycin Disease Interaction
Elimination Route
Poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.
Innovators Monograph
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