patent blue violet
patent blue violet Uses, Dosage, Side Effects, Food Interaction and all others data.
Patent blue is aniline dye and it is one of the most common dyes used. It is a sodium or calcium salt of diethylammonium hydroxide inner salt. It has the chemical designation of (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cyclohexadiene-1-ylidene)diethylammonium hydroxide. Patent blue was developed by Guerbet and approved by Health Canada on December 31, 1979. The isomer isosulphan is used in the United States for the same indications than patent blue.
Administration of patent blue has been reported to cause hypersensitivity reactions in approximately 1% of the patients. It also presents a localized blue coloration which has made patent blue a sensitive and specific option for the detection of micrometastatic cancer in lymph nodes.
| Trade Name | patent blue violet |
| Generic | Patent Blue |
| Patent Blue Other Names | patent blue violet |
| Type | |
| Formula | C27H33N2O7S2 |
| Weight | Average: 561.69 Monoisotopic: 561.172370179 |
| Protein binding | Patent blue gets specifically bound to albumin which allows it to travel through the breast lymphatics. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
patent blue violet is a dye used to label lymphatic vessels, arterial territories, and lymph nodes prior to biopsy in some cancers.
Patent blue is used for marking lymphatic vessels and arterial territories as well as for sentinel lymph node prior to biopsy in patients with operable breast cancer and clinically negative lymph nodes in combination with a radiotracer.
Patent blue is also used in the textile, paper, agriculture and cosmetic industry.
patent blue violet is also used to associated treatment for these conditions: Circulatory Disorders, Sentinel Lymph Node Biopsy
How patent blue violet works
The specific binding of patent blue allows it to freely travel in the breast lymphatics and allows staging with a less invasive alternative. Patent blue will form a complex with albumin which will be picked up by regional afferent lymphatics to identify sentinel lymph nodes. A sentinel lymph node is the first lymph node in a chain or group of lymph nodes that cancer is most likely to spread to. The determination of the sentinel lymph node allows the physician to stage cancer by observing if cancer has spread to the near lymph nodes.
Toxicity
Overdose studies have not been performed but major cases of hypersensitivity have been reported.
Food Interaction
No interactions found.Volume of Distribution
This pharmacokinetic parameter has not been studied.
Elimination Route
Patent blue is selectively absorbed in the lymphatics. When administered orally, patent blue has a very low absorption and limited systemic availability.
Half Life
The elimination half-life is of about 24-48 hours.
Clearance
This pharmacokinetic property has nos been fully studied.
Elimination Route
Patent blue is excreted into the urine and bile.The excretion is more significant in the urine which after the administration of patent blue intravenously can even change to a blue coloration. When administered orally, patent blue is excreted unchanged in feces.
Innovators Monograph
You find simplified version here patent blue violet
