Pegademase

Pegademase Uses, Dosage, Side Effects, Food Interaction and all others data.

Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life.

Used to replace deficient or inactive adenosine deaminase which leads to severe combined immunodeficiency disease (SCID). The enzyme is responsible for converting adenosine to inosine. In the absence of adenosine deaminase, the purine substrates adenosine, 2'-deoxyadenosine and their metabolites are actually toxic to lymphocytes thereby leading to diminished immune function.

Trade Name Pegademase
Availability Discontinued
Generic Pegademase
Pegademase Other Names PEG-adenosine deaminase, pegADA, Pegademase, Pegademase bovine
Related Drugs Adagen, Revcovi
Type
Formula C1821H2834N484O552S14
Weight 40788.2 Da
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Pegademase
Pegademase

Uses

Pegademase is a modified form of bovine adenosine deaminase used to treat adenosine deaminase deficiency, a condition which leads to the formation of adenosine metabolites which are cytotoxic to lymphocytes.

For treatment of adenosine deaminase deficiency

Pegademase is also used to associated treatment for these conditions: Adenosine Deaminase Deficiency

How Pegademase works

Pegademase converts adenosine (toxic) to inosine (less toxic) by deamination. It also converts 2'-deoxyadenosine to 2'-deoxyinosine via deamination.

Pegademase Disease Interaction

Major: bone marrow transplantation, platelet disorders

Elimination Route

Time to peak for plasma adenosine deaminase is 2 to 3 days

Half Life

plasma adenosine deaminase elimination half-life is 3 to >6 days

Innovators Monograph

You find simplified version here Pegademase

*** Taking medicines without doctor's advice can cause long-term problems.
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