Pemirolastum

Pemirolastum Uses, Dosage, Side Effects, Food Interaction and all others data.

Pemirolastum binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Pemirolastum has also been observed to inhibit antigen-stimulated calcium ion influx into mast cells through the blockage of calcium channels. Pemirolastum inhibits the chemotaxis of eosinophils into ocular tissue, and prevents inflammatory mediator release from human eosinophils.

Pemirolastum is used for the prophylactic treatment of itching of the eye associated with allergic conjunctivitis. Pemirolastum potassium is a mast cell stabilizer that inhibits the in vivo Type I immediate hypersensitivity reaction. Pemirolastum inhibits the antigen-induced release of inflammatory mediators (e.g., histamine, leukotriene C4, D4, E4) from human mast cells. Allergic reactions lead to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis and vasodilatation (allowing blood fluids to enter the area to cause swelling). Pemirolastum is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of blood vessels to provide effective, temporary relief of watery and itchy eyes.

Pemirolastum
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Pemirolastum
Generic	Pemirolast
Pemirolast Other Names	Pemirolast, Pemirolastum
Type
Formula	C₁₀H₈N₆O
Weight	Average: 228.2101 Monoisotopic: 228.075958908
Groups	Approved, Investigational
Therapeutic Class	Ophthalmic Non-Steroid drugs
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Pemirolastum ophthalmic solution is used for the prevention of itching of the eye due to allergic conjunctivitis.

Pemirolastum is also used to associated treatment for these conditions: Conjunctivitis allergic, Seasonal Allergic Conjunctivitis

How Pemirolastum works

Pemirolastum binds to the histamine H₁ receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Pemirolastum has also been observed to inhibit antigen-stimulated calcium ion influx into mast cells through the blockage of calcium channels. Pemirolastum inhibits the chemotaxis of eosinophils into ocular tissue, and prevents inflammatory mediator release from human eosinophils.

Dosage

Pemirolastum dosage

Adult: 1 to 2 drops in each affected eye four times daily.

Pediatric Use: Safety and effectiveness in pediatric patients below the age of 3 years have not been established.

Side Effects

Burning of eye, dry eye, ocular discomfort, non ocular allergy, sinusitis, headache and sneezing or nasal congestion.

Precaution

To prevent contaminating the dropper tip and solution, do not touch the eyelids or surrounding areas with the dropper tip. Keep the bottle tightly closed when not in use Patients should be advised not to wear contact lens if their eye is red Pemirolastum should not be used to treat contact lens related irritation Patients should wait 10 minutes after applying Pemirolastum before they insert contact lenses

Food Interaction

No interactions found.

Half Life

4.5 hours (Ophthalmic)

Elimination Route

Following topical administration, about 10-15% of the dose was excreted unchanged in the urine.

Pregnancy & Breastfeeding use

Pregnancy: There are no adequate and well-controlled studies in pregnant women. Pemirolastum ophthalmic solution should be used during pregnancy only if the benefit outweighs the risk.

Lactation: It is not known whether Pemirolastum Potassium is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Pemirolastum ophthalmic solution is administered to a nursing woman.

Contraindication

Pemirolastum ophthalmic solution is contraindicated in patients with previously demonstrated hypersensitivity to any of the ingredients of this product.