Pentastarch Uses, Dosage, Side Effects and more

Pentastarch is an artificial colloid (hydroxyethyl starch derivative). Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation. It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. When administered, pentastarch remains mainly in the circulatory system and hence, it is considered a plasma expander.

Trade Name Pentastarch
Availability Prescription only
Generic Pentastarch
Pentastarch Other Names Pentastarch
Type
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: January 7, 2025 at 1:49 am

Uses

Pentastarch is a plasma volume expander used as an adjunct in the management of shock due to hemorrhage, surgery, sepsis, burns or other trauma.

The primary intended use of pentastarch is as a substitute for older colloids such as albumin or hetastarch for use in plasma volume expansion.

Pentastarch is also used to associated treatment for these conditions: Blood Volume Expansion

Half Life

~2.5 hours.

Elimination Route

As a result of its lower molecular weight and lesser degree of substitution, pentastarch is eliminated from the circulation at a faster rate than hetastarch. Ordinarily, only 10% of an intravenous dose remains after 24 hours, and levels are undetectable after 4 to 7 days. Up to 70% of a dose is excreted in the urine within 24 hours.

Innovators Monograph

*** Taking medicines without doctor's advice can cause long-term problems.
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