Penthrane

Penthrane Uses, Dosage, Side Effects, Food Interaction and all others data.

An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)

Penthrane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.

Trade Name Penthrane
Availability Discontinued
Generic Methoxyflurane
Methoxyflurane Other Names Methoflurane, Methoxyfluoran, Methoxyfluran, Methoxyflurane, Methoxyfluranum, Metoxiflurano
Type
Formula C3H4Cl2F2O
Weight Average: 164.966
Monoisotopic: 163.960726574
Groups Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Penthrane
Penthrane

Uses

For use in the induction and maintenance of general anesthesia

Penthrane is also used to associated treatment for these conditions: Severe Pain, Moderate Pain

How Penthrane works

Penthrane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Penthrane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Penthrane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.

Toxicity

LD50=3600 mg/kg (Orally in rats). Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.

Food Interaction

  • Avoid alcohol. Ingesting alcohol may increase the CNS depressant effects of methoxyflurane.

Penthrane Alcohol interaction

[Moderate] GENERALLY AVOID:

Alcohol may potentiate some of the pharmacologic effects of central nervous system (CNS)-active agents.

Use in combination may result in additive CNS depression and/or impairment of judgment, thinking, and psychomotor skills.

Patients receiving CNS-active agents should be advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled against driving, operating machinery, or engaging in potentially hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Innovators Monograph

You find simplified version here Penthrane

*** Taking medicines without doctor's advice can cause long-term problems.
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