Perflutren lipid microsphere
Perflutren lipid microsphere Uses, Dosage, Side Effects, Food Interaction and all others data.
Perflutren lipid microsphere, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren lipid microsphere enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
Perflutren lipid microsphere, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. It provide contrast enhancement of the endocardial borders during echocardiography. The perflutren lipid microspheres exhibit lower acoustic impedance than blood and enhance the intrinsic backscatter of blood.
| Trade Name | Perflutren lipid microsphere |
| Availability | Prescription only |
| Generic | Perflutren |
| Perflutren Other Names | Freon 218, Octafluoropropane, Octafluorpropan, Oktafluorpropan, Perfluoropropane, Perflutren, Perflutreno |
| Related Drugs | Definity, Optison |
| Type | Intravenous |
| Formula | C3F8 |
| Weight | Average: 188.0193 Monoisotopic: 187.98722564 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Perflutren lipid microsphere is a diagnostic medication to improve contrast during echocardiograms.
Used as an ultrasound contrast imaging in cardiology and radiology.
How Perflutren lipid microsphere works
Perflutren lipid microsphere is comprised of gas-filled microspheres that are injected or infused into the body. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren lipid microsphere enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
Toxicity
There is new temporal evidence that perflutren may be associated with new-onset seizure activity following perflutren microbubble contrast injection during dobutamine-atropine stress echocardiography. [PMID: 23432576]
Food Interaction
No interactions found.Perflutren lipid microsphere Drug Interaction
Major: haloperidolModerate: metronidazole, levofloxacinMinor: sulfamethoxazole / trimethoprimUnknown: contained in alcoholic beverages , thyroid desiccated, bumetanide, mycophenolate mofetil, deferoxamine, hydromorphone, oxybutynin, immune globulin oral, epoprostenol, methenamine, ruxolitinib, levetiracetam, physiological irrigating solution topical, insulin glargine, furosemide, insulin lispro
Perflutren lipid microsphere Disease Interaction
Major: cardiopulmonary reactionsModerate: hepatic impairment
Half Life
The mean half-life of OFP in blood 1.9 minutes
Innovators Monograph
You find simplified version here Perflutren lipid microsphere
