Perifosine
Perifosine Uses, Dosage, Side Effects, Food Interaction and all others data.
Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.
| Trade Name | Perifosine |
| Generic | Perifosine |
| Perifosine Other Names | Perifosine |
| Type | |
| Formula | C25H52NO4P |
| Weight | Average: 461.668 Monoisotopic: 461.363396156 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in solid tumors, multiple myeloma, leukemia (unspecified), lung cancer, and brain cancer.
How Perifosine works
Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis.
Innovators Monograph
You find simplified version here Perifosine
