Permisol Max Lotion 5%+10%

Permisol Max Lotion 5%+10% Uses, Dosage, Side Effects, Food Interaction and all others data.

Permethrin is a pyrethroid pediculocide and scabicide. It causes paralysis and death of the pest by inhibiting sodium ion influx through nerve cell membrane channels delaying repolarisation.

Crotamiton has scabicidal and antipruritic action against Sarcoptes scabei. It is an effective pediculocide as well.

Trade Name Permisol Max Lotion 5%+10%
Generic Permethrin + Crotamiton
Weight 5%+10%
Type Lotion
Therapeutic Class Local Antipruritic, Parasiticidal preparations
Manufacturer ACI Limited
Available Country Bangladesh
Last Updated: October 19, 2023 at 6:27 am
Permisol Max Lotion 5%+10%
Permisol Max Lotion 5%+10%

Uses

This lotion is used for the treatment of scabies and pruritus.

Permisol Max Lotion 5%+10% is also used to associated treatment for these conditions: Pruritis of the skin, ScabiesHead Lice Infestation, Norwegian scabies, Scabies, Lice of the pubic area

How Permisol Max Lotion 5%+10% works

Crotamiton is an antiparasitic that is toxic to the scabies mite. Crotamiton also relieves itching by producing what is called a counter-irritation. As crotamiton evaporates from the skin, it produces a cooling effect. This cooling effect helps to divert your body's attention away from the itching.

Permethrin acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance.

Dosage

Permisol Max Lotion 5%+10% dosage

Adult: Permethrin & Crotamiton lotion is suitable for adults, children of 2 months of age and above, and the elderly. It isfor external use only and should not be applied to broken skin, mucous membranes or near theeyes. Permethrin & Crotamiton lotion should be applied to skin which is clean, dry and cool. It should not be usedimmediately after a hot bath. Permethrin & Crotamiton lotion is intended for a single application over the wholebody. Permethrin & Crotamiton lotion should be left on for at least 8 hours. Reapply the lotion to the hands if theyare washed within 8 hours of treatment. The whole body should be washed thoroughly 8-12hours after application.Adults & children over 2 years: Apply the lotion over the whole body but not the head and face.Pay particular attention to the areas between fingers and toes, under nails, wrists, armpits,external genitalia, breasts and buttocks.

The elderly: Apply the lotion over the whole body including the neck, face, ears and scalp. Payparticular attention to the areas between fingers and toes, under nails, wrists, armpits, externalgenitalia, breasts and buttocks. Avoid the area close to the eyes.

Children under 2 years: Children under 2 years should only be treated under medical supervision.Apply the lotion over the whole body including the neck, face, ears and scalp. Pay particularattention to the areas between fingers and toes, under nails, wrists, armpits, palms of hands andsoles of feet, external genitals and buttocks. Avoid the area around the mouth where the lotioncould be licked off and the area around the eyes

Lotion should be applied to clean, dry skin. If the body is hot due to warm bath or any other reason, skin should be allowed to cool. It should be applied to the whole body excluding head. The whole body should be washed thoroughly 8-12 hours after treatment. On the next day cloths and bed sheets should be cleaned with warm water. The lotion should be applied if lotion is washed out by water. Other members of the family should use this lotion as preventive in the same way due to its highly contagious effects. The lotion should not be applied to the vicinity of mouth and areas close to eyes.

Side Effects

Occasional reports of burning or stinging sensation which passes quickly. This is usually mild and occurs more frequently in patients with severe scabies. Transient signs and symptoms of skin irritation including rash or itching, erythema, edema and eczema. These are generally considered to be part of the natural history of scabies.

Toxicity

Oral, rat LD50: 430 - 4000 mg/kg; skin, rabbit LD50: 2000 mg/kg.

Precaution

This lotion should be kept out of the reach of children. This lotion is for external use only. Nursing staff who routinely apply this lotion may wish to wear gloves to avoid any possible irritation to the hand. Avoid contact with the eyes. The lotion can cause eye irritation. If lotion goes to the eyes, rinse with water immediately.

Interaction

The treatment of eczematous-like reactions with corticosteroids should be withheld prior to treatment with permethrin, as there is a risk of exacerbating the scabies infestation by reducing the immune response to the mite. The likelihood of interactions between the two treatments leading to potentiated adverse reactions or reduced efficacy is, however small.

Elimination Route

10 % absorbed when applied locally.

Poorly absorbed through the skin.

Elimination Route

Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.

Pregnancy & Breastfeeding use

There is no experience to judge the safety of permethrin & crotamiton in pregnancy, therefore it is not recommended during pregnancy, especially in the first three months. It is not known whether the active substance passes into breast milk. Nursing mothers should avoid applying it in the area of the nipples.

Contraindication

Combination of permethrin 5% and crotamiton 10% is contra-indicated in patients with known hypersensitivity to permethrin or crotamiton.

Special Warning

Children: Application as described for adults but in children under 3 years of age Cronix lotion should not be applied more than once a day.

Acute Overdose

There are no reports of overdosage of permethrin & crotamiton. Excessive application to the skin might result in local adverse reactions. In the event of accidental ingestion by a child, gastric lavage should be considered if within 2 hours of ingestion. Treatment of hypersensitivity reactions should be symptomatic.

Storage Condition

Store in a cool place (do not store above 25° C & do not freeze) and protected from light.

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*** Taking medicines without doctor's advice can cause long-term problems.
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