Pertechnetate-99Tc

Pertechnetate-99Tc Uses, Dosage, Side Effects, Food Interaction and all others data.

Pertechnetate-99Tc is a radiopharmaceutical diagnostic agent composed of an oxoanion with the chemical formula TcO4-. Pertechnetate has a wide variety of uses within nuclear medicine as it distributes within the body to a similar extent as iodine. It also concentrates in the thyroid gland, salivary glands, gastric mucosa, and choroid plexus. However, in contrast to the iodide ion, the pertechnetate ion is released unchanged from the thyroid gland. Currently marketed as the product Drytec, technetium-99m pertechnetate is indicated for imaging of the following tissues: thyroid, salivary gland, urinary bladder (for detection of vesico-ureteral reflux), and the nasolacrimal drainage system.

Technetium-99m's short half life (6 hours) makes storage impossible, therefore it is supplied as its parent nuclide molybdenum-99, which spontaneously decays to technetium-99 through beta decay. This is normally supplied in a hospital setting through the use of a technetium-99m generator, whereby technetium exits the generator in the form of the pertechnetate ion, TcO4−, which can be extracted and promptly used for clinical diagnostics. Following intravenous injection, single photon emission computed tomography (SPECT) is performed to detect the gamma ray emmitted by the decay of Technetium-99m to Technetium-99.

Pertechnetate-99Tc
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Dosage
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Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Interaction With other Medicine
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Trade Name	Pertechnetate-99Tc
Generic	Technetium Tc-99m pertechnetate
Technetium Tc-99m pertechnetate Other Names	(99Tc)pertechnetate, CPERT, GPERT, Pertechnetate-99Tc, Technetium (99mTc) Pertechnetate, Technetium Tc 99m Pertechnetate
Type
Formula	H₈O₄Tc
Weight	Average: 169.968 Monoisotopic: 169.95002301
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Pertechnetate-99Tc is a radiocontrast agent used for the identification of various organs, including but not limited to the brain, thyroid, placenta, and bladder.

Sodium Pertechnetate Tc99m Injection is indicated for use in adults for imaging in the following tissues: thyroid, salivary gland, urinary bladder (for detection of vesico-ureteral reflux), and nasolacrimal drainage system (dacryoscintigraphy). It is indicated for use in children for imaging the following tissues: thyroid and urinary bladder.

Pertechnetate-99Tc is also used to associated treatment for these conditions: Vesico-Ureteral Reflux

How Pertechnetate-99Tc works

The pertechnetate ion distributes in the body similarly to the iodide ion, but is not organified when trapped in the thyroid gland. It also concentrates in the thyroid gland, salivary glands, gastric mucosa, and choroid plexus. However, in contrast to the iodide ion, the pertechnetate ion is released unchanged from the thyroid gland.