PGF2A THAM

PGF2A THAM Uses, Dosage, Side Effects, Food Interaction and all others data.

The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. PGF2A THAM may also be known as dinoprost trometamol, PGF2 alpha THAM, or prostaglandin F2 alpha tromethamine.

PGF2A THAM is the tromethamine (THAM) salt of the naturally occurring prostaglandin F2alpha. Prostaglandin F2alpha has several pharmacologic effects on the female reproductive system, including stimulation of myometrial activity, relaxation of the cervix, inhibition of steroidogenesis by corpora lutea, and can potentially lyse corpora lutea.

Trade Name PGF2A THAM
Generic Dinoprost tromethamine
Dinoprost tromethamine Other Names Dinoprost trometamol, Dinoprost tromethamine, PGF2-alpha THAM, PGF2A THAM, PGF2alpha THAM, Prostin F2 Alpha
Type
Formula C24H45NO8
Weight Average: 475.616
Monoisotopic: 475.314517421
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
PGF2A THAM
PGF2A THAM

Uses

Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life. Also used at low-doses for medically indicated induction of labor at term. Also injected intra-arterially for use as a vasodilator to assist in angiography.

How PGF2A THAM works

PGF2A THAM appears to act directly on the myometrium, but this has not been completely established. Dinoprost stimulates myometrial contractions (via its interaction with the prostaglandin receptors) in the gravid uterus that are similar to the contractions that occur in the term uterus during labor. These contractions are usually sufficient to cause abortion. Uterine response to prostaglandins increases gradually throughout pregnancy. Dinoprost also facilitates cervical dilatation and softening.

Toxicity

Although overdose by intra-amniotic administration of dinoprost has not been reported, exaggeration of the nausea, vomiting, and diarrhea that occur with normal doses would be expected.

Elimination Route

Slowly absorbed from the amniotic fluid into systemic circulation.

Half Life

The half-life of dinoprost in amniotic fluid is 3 to 6 hours. The plasma half-life of dinoprost after intravenous administration is reported to be less than 1 minute.

Innovators Monograph

You find simplified version here PGF2A THAM

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000012
http://classyfire.wishartlab.com/tax_nodes/C0003909
http://classyfire.wishartlab.com/tax_nodes/C0000513
http://classyfire.wishartlab.com/tax_nodes/C0000514
http://classyfire.wishartlab.com/tax_nodes/C0002949
http://classyfire.wishartlab.com/tax_nodes/C0000341
http://classyfire.wishartlab.com/tax_nodes/C0000339
http://classyfire.wishartlab.com/tax_nodes/C0002938
http://classyfire.wishartlab.com/tax_nodes/C0001292
http://classyfire.wishartlab.com/tax_nodes/C0001137
http://classyfire.wishartlab.com/tax_nodes/C0001205
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:31502
http://www.hmdb.ca/metabolites/HMDB0015291
http://www.genome.jp/dbget-bin/www_bget?drug:D01352
http://www.genome.jp/dbget-bin/www_bget?cpd:C12786
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5282415
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509164
https://www.chemspider.com/Chemical-Structure.4445570.html
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=23321
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=31502
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1200896
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000826
http://www.pharmgkb.org/drug/PA164781385
https://en.wikipedia.org/wiki/Prostaglandin_F2alpha
*** Taking medicines without doctor's advice can cause long-term problems.
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