Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml Uses, Dosage, Side Effects and more
Each ml sterile eye drops contains- Adenosine BP 2 mg Cytochrome-C Ph. Gr. 0.5 mg Sodium Succinate Ph. Gr. 0.6 mg Nicotinamide BP 10 mg. Preservative: Thiomersal 0.005%| Trade Name | Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml |
| Generic | Adenosine + Cytochrome-C + Sodium Succinate + Nicotinamide |
| Weight | (2 mg+0.5 mg +0.6 mg+10 mg)/ml |
| Type | Ophthalmic Solution |
| Therapeutic Class | Drugs for lens opacification |
| Manufacturer | OSL Pharma Limited |
| Available Country | Bangladesh |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
This eye drops is used for the treatment of lens opacification.Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml is also used to associated treatment for these conditions: Paroxysmal Supraventricular Tachycardia, SVT, Tachycardia, Supraventricular, Symptomatic pulmonary arterial hypertension (PAH)Gastrointestinal insufficiency, Hepatic Insufficiency, Macrocytic anemia, Secondary anemia, Vitamin Deficiency, Severe debilitation, Dietary and Nutritional Therapies, Nutritional supplementation, Dietary supplementation
How Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml works
Agonism of adenosine receptors A1 and A2 reduces conduction time in the atrioventricular node of the heart. Conduction time is decreased by inducing potassium efflux and inhibiting calcium influx through channels in nerve cells, leading to hyperpolarization and and increased threshold for calcium dependent action potentials. Decreased conduction time leads to an antiarrhythmic effect. Inhibition of calcium influx, reduces the activity of adenylate cyclase, relaxing vascular smooth muscle. Relaxed vascular smooth muscle leads to increased blood flow through normal coronary arteries but not stenotic arteries, allowing thallium-201 to be more readily uptaken in normal coronary arteries.
Dosage
Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml dosage
One drop into the affected eye twice daily.Side Effects
Like any active ingredient, this drug may cause more or less discomfort in some patients. If you feel any discomfort, inform your doctor.Toxicity
Patients experiencing an overdose of adenosine may present with asystole, heart block, or cardiac ischemia; though the effects are generally short lived. Patients experiencing an overdose should be treated with symptomatic and supportive care, which may include a slow intravenous injection of theophylline.
The LD50 in mice is >20 g/kg subcutaneously, 500mg/kg intraperitoneally, and 39.6 µg/kg subcutaneously.[L32048]
Precaution
Do not inject or swallow. In case of concomitant treatment with another ophthalmic solution, wait 15 minutes between each instillation.Interaction
In order to avoid any interaction between different medical products, inform your doctor of any other ongoing treatment in particular with other eye drops.Volume of Distribution
Data regarding the volume of distribution of adenosine are not readily available.
Elimination Route
Data regarding the absorption of adenosine are not readily available.
Half Life
The half life of adenosine in blood is less than 10 seconds.
Clearance
Data regarding the clearance of adenosine are not readily available.
Elimination Route
Adenosine is predominantly eliminated in the urine as uric acid.
