Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml

Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml Uses, Dosage, Side Effects, Food Interaction and all others data.

Each ml sterile eye drops contains- Adenosine BP 2 mg Cytochrome-C Ph. Gr. 0.5 mg Sodium Succinate Ph. Gr. 0.6 mg Nicotinamide BP 10 mg. Preservative: Thiomersal 0.005%

Table Of contents

• Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml
Generic	Adenosine + Cytochrome-C + Sodium Succinate + Nicotinamide
Weight	(2 mg+0.5 mg +0.6 mg+10 mg)/ml
Type	Ophthalmic Solution
Therapeutic Class	Drugs for lens opacification
Manufacturer	OSL Pharma Limited
Available Country	Bangladesh
Last Updated:	October 19, 2023 at 6:27 am

Uses

This eye drops is used for the treatment of lens opacification.

Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml is also used to associated treatment for these conditions: Paroxysmal Supraventricular Tachycardia, SVT, Tachycardia, Supraventricular, Symptomatic pulmonary arterial hypertension (PAH)Gastrointestinal insufficiency, Hepatic Insufficiency, Macrocytic anemia, Secondary anemia, Vitamin Deficiency, Severe debilitation, Dietary and Nutritional Therapies, Nutritional supplementation, Dietary supplementation

How Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml works

Agonism of adenosine receptors A1 and A2 reduces conduction time in the atrioventricular node of the heart. Conduction time is decreased by inducing potassium efflux and inhibiting calcium influx through channels in nerve cells, leading to hyperpolarization and and increased threshold for calcium dependent action potentials. Decreased conduction time leads to an antiarrhythmic effect. Inhibition of calcium influx, reduces the activity of adenylate cyclase, relaxing vascular smooth muscle. Relaxed vascular smooth muscle leads to increased blood flow through normal coronary arteries but not stenotic arteries, allowing thallium-201 to be more readily uptaken in normal coronary arteries.

Dosage

Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml dosage

One drop into the affected eye twice daily.

Side Effects

Like any active ingredient, this drug may cause more or less discomfort in some patients. If you feel any discomfort, inform your doctor.

Toxicity

Patients experiencing an overdose of adenosine may present with asystole, heart block, or cardiac ischemia; though the effects are generally short lived. Patients experiencing an overdose should be treated with symptomatic and supportive care, which may include a slow intravenous injection of theophylline.

The LD₅₀ in mice is >20 g/kg subcutaneously, 500mg/kg intraperitoneally, and 39.6 µg/kg subcutaneously.[L32048]

Precaution

Do not inject or swallow. In case of concomitant treatment with another ophthalmic solution, wait 15 minutes between each instillation.

Interaction

In order to avoid any interaction between different medical products, inform your doctor of any other ongoing treatment in particular with other eye drops.

Volume of Distribution

Data regarding the volume of distribution of adenosine are not readily available.

Elimination Route

Data regarding the absorption of adenosine are not readily available.

Half Life

The half life of adenosine in blood is less than 10 seconds.

Clearance

Data regarding the clearance of adenosine are not readily available.

Elimination Route

Adenosine is predominantly eliminated in the urine as uric acid.

Pregnancy & Breastfeeding use

As a general rule, it is recommended to ask your doctor for advice before using this medicine if you are pregnant or nursing mother.

Contraindication

This eye drops is contraindicated in patients with known hypersensitivity to any ingredient of the product.

Acute Overdose

Accidental ingestion of the medicine is unlikely to cause any toxicity due to low content of ingredients.

Storage Condition

Store in below 25⁰C temperature and away from light. Keep out of reach of children. Do not touch the dropper tip to surfaces since this may contaminate the solution. After one month of the opening do not use the medicine of dropper.

Innovators Monograph

You find simplified version here Phacomin Ophthalmic Solution (2 mg+0.5 mg +0.6 mg+10 mg)/ml