Phenmetrazin
Phenmetrazin Uses, Dosage, Side Effects, Food Interaction and all others data.
A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine.
Phenmetrazin is a sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. Phenmetrazin was originally sold under the tradename Preludin as an anorectic. It has since been removed from the market. It is by some considered to have a greater potential for addiction than the amphetamines, and has been abused in many countries, for example Sweden.
| Trade Name | Phenmetrazin |
| Generic | Phenmetrazine |
| Phenmetrazine Other Names | Fenmetrazin, Fenmetrazina, Phenmetrazin, Phenmetrazine, Phenmetrazinum |
| Type | |
| Formula | C11H15NO |
| Weight | Average: 177.2429 Monoisotopic: 177.115364107 |
| Groups | Approved, Illicit |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used as an anorectic in the treatment of obesity.
How Phenmetrazin works
Phenmetrazin is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron leading to an increase in the release of these monoamines into the extraneuronal space. Dopamine integrates incoming sensory stimuli, initiates and controls fine movement (nigro-neostriatal pathway), controls emotional behavior (midbrain mesolimbic-forebrain system) and controls hypothalamic-pituitary endocrine system (tubero-infundibular system). It is this latter effect on the tubero-infundibular systm that seems to lead to reduced food intake. Phenmetrazin also acts as a monoamine oxidase inhibitor.
Toxicity
Adult monkeys have an LD50 of 15 to 20 mg/kg, whereas for young monkeys the LD50 is only 5 mg/kg. Symptoms of overdose include acute central nervous system stimulation, cardiotoxicity causing tachycardia, arrhythmias, hypertension, and cardiovascular collapse. Whilst some patients show signs of toxicity at blood concentrations of 20 µg/L, chronic abusers of amphetamine have been known to have blood concentration of up to 3000 µg/L.
Elimination Route
Readily absorbed from the gastro-intestinal tract and buccal mucosa.
Half Life
16 to 31 hours
Innovators Monograph
You find simplified version here Phenmetrazin
