Phenprocoumarole

Phenprocoumarole Uses, Dosage, Side Effects, Food Interaction and all others data.

Coumarin derivative that acts as a long-acting oral anticoagulant.

Phenprocoumarole, a coumarin anticoagulant, thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as phenprocoumon have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae.

Phenprocoumarole
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Phenprocoumarole
Generic	Phenprocoumon
Phenprocoumon Other Names	Fenprocumon, Fenprocumone, Phenprocoumarol, Phenprocoumarole, Phenprocoumon, Phenprocoumone, Phenprocoumonum, Phenprocumone
Type
Formula	C₁₈H₁₆O₃
Weight	Average: 280.3178 Monoisotopic: 280.109944378
Protein binding	99%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Phenprocoumarole is an anticoagulant drug used for the prevention of thrombosis.

Used for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).

Phenprocoumarole is also used to associated treatment for these conditions: Embolism venous, Myocardial Infarction, Thrombotic events

How Phenprocoumarole works

Phenprocoumarole inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.

Toxicity

50=500 mg/kg. Symptoms of overdose includes suspected or overt abnormal bleeding (e.g., appearance of blood in stools or urine, hematuria, excessive menstrual bleeding, melena, petechiae, excessive bruising or persistent oozing from superficial injuries).

Food Interaction

Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
Ensure consistent Vitamin K intake. Changes in vitamin K intake may impact coagulation.
Exercise caution with grapefruit products.
Exercise caution with St. John's Wort.