Phenurone
Phenurone Uses, Dosage, Side Effects, Food Interaction and all others data.
Phenurone is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.
Phenurone is a ureal anticonvulsant indicated for control of severe epilepsy, particularly mixed forms of complex partial (psychomotor or temporal lobe) seizures, refractory to other anticonvulsants. Phenurone elevates the threshold for minimal electroshock convulsions and abolishes the tonic phase of maximal electroshock seizures. It also prevents or modifies seizures induced by pentylenetetrazol or other convulsants.
Trade Name | Phenurone |
Availability | Discontinued |
Generic | Phenacemide |
Phenacemide Other Names | Phenacemide |
Type | |
Formula | C9H10N2O2 |
Weight | Average: 178.1879 Monoisotopic: 178.074227574 |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used to control certain seizures in the treatment of epilepsy.
How Phenurone works
Phenurone binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronization. Hypersynchronization is what often causes seizures.
Toxicity
Oral, mouse: LD50 = 987 mg/kg; Oral, rabbit: LD50 = 2500 mg/kg; Oral, rat: LD50 = 1600 mg/kg
Food Interaction
- Take with or without food. Co-administration with food may reduce gastrointestinal upset.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Phenurone Disease Interaction
Elimination Route
Almost completely absorbed.
Half Life
22-25 hours.
Innovators Monograph
You find simplified version here Phenurone