Phenylsalicylate

Phenylsalicylate Uses, Dosage, Side Effects, Food Interaction and all others data.

Phenylsalicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in Aspirin ). Phenylsalicylate may also be found in some antiseptic agents . It is synthesized by heating salicylic acid with phenol , .

Phenylsalicylate is used as a food additive in the USA .

This compound belongs to the class of organic compounds known as depsides and depsidones. These are polycyclic compounds that is either a polyphenolic compound composed of two or more monocyclic aromatic units linked by an ester bond (depside), or a compound containing the depsidone structure (depsidone) .

Phenylsalicylate
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Phenylsalicylate
Generic	Phenyl salicylate
Phenyl salicylate Other Names	Salol
Type
Formula	C₁₃H₁₀O₃
Weight	Average: 214.2167 Monoisotopic: 214.062994186
Protein binding	Please refer to Aspirin for protein binding of salicylates.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	Russia
Last Updated:	September 19, 2023 at 7:00 am

Uses

Pain and fever .

How Phenylsalicylate works

Inhibits the activity of the enzyme known as cyclooxygenase (COX) which causes the formation of prostaglandins, substances which cause inflammation, swelling, pain, and fever . For more information, refer to the drug entry Aspirin.

Toxicity

Oral LD50 in the rat is 3000 mg/kg

Adverse effects can be divided into several categories , :

Eyes: irritation

Skin: skin irritation

Cardiovascular: rapid pulse, flushing

Central Nervous System —blurred vision, dizziness

Respiratory —shortness of breath or troubled breathing , irritation of respiratory system

Genitourinary —difficult micturition, acute urinary retention

Gastrointestinal —dry mouth, nausea/vomiting

Overdosage may be managed by inducing emesis or gastric lavage. Slow intravenous administration of physostigmine in doses of 1 to 4 mg (0.5 to 1 mg in children) repeated as needed in 1-2 h to relieve severe antimuscarinic symptoms. Administration of small doses of diazepam to control excitement and seizures may be warranted. Artificial respiration with oxygen can be used if needed for respiratory depression. Adequate hydration is important, as well as symptomatic treatment, provided as necessary .

Food Interaction

No interactions found.

Volume of Distribution

Steady-state plasma salicylate concentrations increase more than proportionally with increasing dosages; the time required to reach steady state increases with increasing daily dose. Dosage intervals of 8-12 h are sufficient to maintain plasma salicylate concentrations in the normal therapeutic anti-inflammatory concentration range .