Photofrin

Photofrin Uses, Dosage, Side Effects, Food Interaction and all others data.

The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.

Porfimer is a photosensitizing agent used in the photodynamic therapy (PDT) of tumors. Porfimer is indicated for the palliation of patients with completely obstructing esophageal cancer, or of patients with partially obstructing esophageal cancer who cannot be satisfactorily treated with Nd:YAG laser therapy, reduction of obstruction and palliation of symptoms in patients with completely or partially obstructing endobronchial nonsmall cell lung cancer (NSCLC), and the treatment of microinvasive endobronchial NSCLC in patients for whom surgery and radiotherapy are not indicated. The cytotoxic and antitumor actions of porfimer are light and oxygen dependent. Tumor selectivity in treatment occurs through a combination of selective retention of porfimer and selective delivery of light.

Photofrin
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Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
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Interaction With other Medicine
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Trade Name	Photofrin
Generic	Porfimer sodium
Porfimer sodium Other Names	Porfimer natrium, Porfimer sodico, Porfimer sodium, Porfimère sodique, Porfimerum natricum
Weight	75mg,
Type	Intravenous powder for injection
Protein binding	~90%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer	Axcan Pharma Internacional, BV
Available Country	Canada, United States, Portugal,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Photofrin is a hematoporphyrin derivative used to treat esophageal cancer, endobronchial cancer, and high grade dysplasia in Barrett's Esophagus.

Indicated in the treatment of esophageal cancer.

Photofrin is also used to associated treatment for these conditions: Esophageal Cancers, Esophagus, Barrett, Completely obstructive Non-small cell lung cancer, Microinvasive endobrachial Non-small cell lung cancer, Partially obstructive Non-small cell lung cancer

How Photofrin works

Cellular damage caused by porfimer is a consequence of the propagation of radical reactions. Radical initiation may occur after porfimer absorbs light to form a porphyrin excited state. Spin transfer from porfimer to molecular oxygen may then generate singlet oxygen. Subsequent radical reactions can form superoxide and hydroxyl radicals. Tumor death also occurs through ischemic necrosis secondary to vascular occlusion that appears to be partly mediated by thromboxane A2 release.