Physiomycine

Physiomycine Uses, Dosage, Side Effects, Food Interaction and all others data.

A broad-spectrum semisynthetic antibiotic related to tetracycline but excreted more slowly and maintaining effective blood levels for a more extended period.

Methacycline is a tetracycline antibiotic. Similar to other tetracyclines, it has a wide spectrum of antimicrobial action. It is active against most Gram-positive bacteria (pneumococci, streptococci, staphylococci) and Gram-negative bacteria (E. coli, salmonella, shigella, etc.), and towards agents causing onithosis, psittacosis, trachoma, and some Protozoa. Like other tetracyclines, the general usefulness of methacycline has been reduced with the onset of bacterial resistance.

Trade Name Physiomycine
Generic Metacycline
Metacycline Other Names Metaciclina, Metacycline, Methacycline, Methacyclinum, Methylenecycline, Tri-methacycline
Type
Formula C22H22N2O8
Weight Average: 442.424
Monoisotopic: 442.137615676
Protein binding

75-78% protein bound

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country France, Tunisia
Last Updated: September 19, 2023 at 7:00 am
Physiomycine
Physiomycine

Uses

For the treatment of acute bacterial exacerbations of chronic bronchitis

How Physiomycine works

Methacycline, a tetracycline antibiotic, is a protein synthesis inhibitors, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. Methacycline inhibits cell growth by inhibiting translation. It binds to the 16S part of the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Tetracyclines also have been found to inhibit matrix metalloproteinases. This mechanism does not add to their antibiotic effects, but has led to extensive research on chemically modified tetracyclines or CMTs (like incyclinide) for the treatmet of rosacea, acne, and various types of neoplasms.

Elimination Route

58% absorbed

Half Life

14 hours

Innovators Monograph

You find simplified version here Physiomycine

*** Taking medicines without doctor's advice can cause long-term problems.
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