Piperacillin Na Sawai
Piperacillin Na Sawai Uses, Dosage, Side Effects, Food Interaction and all others data.
Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics.
Piperacillin Na Sawai is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Piperacillin Na Sawai has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Piperacillin Na Sawai results from the inhibition of cell wall synthesis and is mediated through Piperacillin Na Sawai binding to penicillin binding proteins (PBPs). Piperacillin Na Sawai is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
| Trade Name | Piperacillin Na Sawai |
| Availability | Prescription only |
| Generic | Piperacillin |
| Piperacillin Other Names | Piperacilina, Piperacillin, Piperacillina, Pipéracilline, Piperacillinum |
| Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin |
| Type | |
| Formula | C23H27N5O7S |
| Weight | Average: 517.555 Monoisotopic: 517.163118933 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Japan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Piperacillin Na Sawai is a penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase generating strains of several bacteria.
For the treatment of polymicrobial infections.
Piperacillin Na Sawai is also used to associated treatment for these conditions: Animal bite, Complicated Appendicitis, Pelvic Inflammatory Disease (PID), Peritonitis, Postpartum Endometritis, Surgical Site Infections, Moderate Bacterial Infections, Moderate Community acquired pneumonia, Moderate Nosocomial pneumonia, Severe Bacterial Infections, Severe Nosocomial pneumonia, Uncomplicated skin and subcutaneous tissue bacterial infections
How Piperacillin Na Sawai works
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin Na Sawai inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin Na Sawai interferes with an autolysin inhibitor.
Food Interaction
No interactions found.Piperacillin Na Sawai Hypertension interaction
[Moderate] Parenteral piperacillin sodium contains approximately 43 mg (1.85 mEq) of sodium per each gram of piperacillin activity.
The combination, piperacillin-tazobactam, contains approximately 54 mg (2.35 mEq) of sodium per gram of piperacillin, or 108 mg (4.7 mEq) per 2.25 gram of total drug.
The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.
In addition, hypokalemia has been reported rarely during therapy with piperacillin and other extended-spectrum penicillin antibiotics, which may be particularly important to bear in mind when treating patients with low potassium reserves or fluid and electrolyte imbalance.
Clinical monitoring of electrolytes is recommended if these agents are used for prolonged periods.
Piperacillin Na Sawai Drug Interaction
Unknown: aspirin, amoxicillin / clavulanate, ciprofloxacin, sulfamethoxazole / trimethoprim, docusate, meperidine, furosemide, enoxaparin, esomeprazole, amlodipine, acetaminophen, clopidogrel, pantoprazole, valproic acid, thiamine, cyanocobalamin, pyridoxine, cholecalciferol, phytonadione, ondansetron
Piperacillin Na Sawai Disease Interaction
Major: colitisModerate: coagulation abnormalities, renal dysfunction, hemodialysis, cystic fibrosis, seizures, sodium/potassium
Volume of Distribution
- 101 mL/kg [intravenous administration of 50 mg/kg (5-minute infusion) in neonates]
Elimination Route
Not absorbed following oral administration.
Half Life
36-72 minutes
Clearance
- 32 - 41 mL/min/1.73 m2
- 124 - 160 mL/min/1.73 m2 [older pediatric patients]
Elimination Route
As with other penicillins, PIPRACIL is eliminated primarily by glomerular filtration and tubular secretion; it is excreted rapidly as unchanged drug in high concentrations in the urine. Because PIPRACIL is excreted by the biliary route as well as by the renal route, it can be used safely in appropriate dosage in patients with severely restricted kidney function.
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