Piportil Depot

Piportil Depot Uses, Dosage, Side Effects, Food Interaction and all others data.

Piportil Depot has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.

Piportil Depot has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It reduces activity of dopamine receptors in the limbic system. Its 5-HT antagonism helps normalize dopamine activity in the cortical regions.

Trade Name Piportil Depot
Generic Pipotiazine
Pipotiazine Other Names Piportil, Pipothiazine, Pipotiazina, Pipotiazine, Pipotiazinum
Type
Formula C24H33N3O3S2
Weight Average: 475.667
Monoisotopic: 475.196333317
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country United Kingdom
Last Updated: September 19, 2023 at 7:00 am
Piportil Depot
Piportil Depot

Uses

Piportil Depot is an antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients.

For the maintenance treatment of chronic non-agitated schizophrenic patients.

Piportil Depot is also used to associated treatment for these conditions: Chronic Schizophrenia

How Piportil Depot works

Piportil Depot acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).

Toxicity

Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.

Food Interaction

  • Avoid alcohol.
  • Take with food. Food decreases irritation.

Innovators Monograph

You find simplified version here Piportil Depot

*** Taking medicines without doctor's advice can cause long-term problems.
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