Пипортил
Пипортил Uses, Dosage, Side Effects, Food Interaction and all others data.
Пипортил has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.
Пипортил has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It reduces activity of dopamine receptors in the limbic system. Its 5-HT antagonism helps normalize dopamine activity in the cortical regions.
Trade Name | Пипортил |
Generic | Pipotiazine |
Pipotiazine Other Names | Piportil, Pipothiazine, Pipotiazina, Pipotiazine, Pipotiazinum |
Type | |
Formula | C24H33N3O3S2 |
Weight | Average: 475.667 Monoisotopic: 475.196333317 |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | Russia |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Пипортил is an antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients.
For the maintenance treatment of chronic non-agitated schizophrenic patients.
Пипортил is also used to associated treatment for these conditions: Chronic Schizophrenia
How Пипортил works
Пипортил acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Toxicity
Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.
Food Interaction
- Avoid alcohol.
- Take with food. Food decreases irritation.
Innovators Monograph
You find simplified version here Пипортил