Pirovon Dt

Pirovon Dt Uses, Dosage, Side Effects, Food Interaction and all others data.

Pirovon Dt is an NSAID, belonging to the oxicam group. It reversibly inhibits cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, which results in decreased formation of prostaglandin precursors.

Pirovon Dt is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Pirovon Dt works by reducing hormones that cause inflammation and pain in the body. Pirovon Dt is used to reduce the pain, inflammation, and stiffness caused by rheumatoid arthritis and osteoarthritis.

Trade Name Pirovon Dt
Availability Prescription only
Generic Piroxicam
Piroxicam Other Names Piroxicam, Piroxicam betadex, Piroxicamum, Pyroxycam
Related Drugs Humira, Buprenex, aspirin, prednisone, ibuprofen, acetaminophen, tramadol, meloxicam, naproxen, diclofenac
Type Tablet
Formula C15H13N3O4S
Weight Average: 331.346
Monoisotopic: 331.062676609
Groups Approved, Investigational
Therapeutic Class Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Manufacturer Bionova Lifesciences
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Pirovon Dt
Pirovon Dt

Uses

Carefully consider the potential benefits and risks of Pirovon Dt and other treatment options before deciding to use Pirovon Dt. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. Pirovon Dt is used for relief of the signs and symptoms of osteoarthritis, for relief of the signs and symptoms of rheumatoid arthritis.

Pirovon Dt is also used to associated treatment for these conditions: Ankylosing Spondylitis (AS), Osteoarthritis (OA), Rheumatoid Arthritis

How Pirovon Dt works

The antiinflammatory effect of Pirovon Dt may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. The prostaglandins are produced by an enzyme called Cox-1. Pirovon Dt blocks the Cox-1 enzyme, resulting into the disruption of production of prostaglandins. Pirovon Dt also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.

Dosage

Pirovon Dt dosage

Oral-

Ankylosing spondylitis, Osteoarthritis, Rheumatoid arthritis:

  • Adult: 20 mg daily as a single dose, divided doses may be used if necessary. Treatment should be reviewed w/in 14 days of starting.
  • Elderly: Use the lowest effective dose for the shortest duration.

Should be taken with food.

Side Effects

Oedema, CHF, HTN, syncope, tachycardia; anorexia, abdominal pain, constipation, diarrhoea, dyspepsia, flatulence, heartburn, nausea, vomiting, dry mouth, esophagitis, gastritis, glossitis, haematemesis, melaena, stomatitis; anaemia, increased bleeding time, ecchymosis, eosinophilia, epistaxis, leucopenia, thrombocytopenia; cystitis, dysuria, haematuria, hyperkalaemia, interstitial nephritis, nephritic syndrome, oliguria/polyuria, proteinuria, renal failure; dizziness, headache, anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness, insomnia, malaise, nervousness, paraesthesia, somnolence, tremors, vertigo; tinnitus, blurred vision; elevated LFT results; pruritus, rash, alopecia, bruising, desquamation, erythema, petechial rash, photosensitivity, purpura, sweating, serum sickness-like reactions; fever, infection, sepsis, wt changes, asthma, dyspnoea.

Toxicity

Symptoms of overdose include drowsiness, nausea, stomach pain, and/or vomiting.

Precaution

Patient with known CV disease or risk factors for CV disease, fluid retention or heart failure, cerebrovascular disease, uncontrolled HTN, asthma. Elderly. Renal and hepatic impairment. Pregnancy and lactation.

Interaction

Increased risk of GI bleeding with anti-platelets and SSRIs. May exacerbate cardiac failure, reduce GFR and increase plasma glycoside levels. Increased risk of nephrotoxicity with ciclosporin and tacrolimus. Increased absorption with cimetidine. Increased risk of GI ulceration with corticosteroids. May interfere with the natriuretic action of diuretics. May displace other highly protein-bound drugs. May increase steady state plasma lithium levels. May antagonise the effect of antihypertensives. May reduce the excretion of methotrexate, leading to acute toxicity. Increased risk of convulsions with quinolones. May interfere with mifepristone-mediated termination of pregnancy.

Food Interaction

  • Avoid alcohol.
  • Take with food.

Pirovon Dt Alcohol interaction

[Moderate] GENERALLY AVOID:

The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss.

The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.



Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

Pirovon Dt Hypertension interaction

[Major] Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure.

Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.

Hypertension interaction

[Moderate] Nonsteroidal anti-inflammatory drugs (NSAIDs), including topicals, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events.

NSAIDs should be used with caution in patients with hypertension.

Blood pressure should be monitored closely during the initiation of NSAID therapy and throughout the course of therapy.

Volume of Distribution

  • 0.14 L/kg

Elimination Route

Well absorbed following oral administration.

Half Life

30 to 86 hours

Elimination Route

Pirovon Dt and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a piroxicam dose is excreted unchanged. However, a substantial portion of piroxicam elimination occurs by hepatic metabolism. Pirovon Dt is excreted into human milk.

Pregnancy & Breastfeeding use

Pregnancy catagort C (in 1st & 2nd trimester), D (in 3rd trimester)

Contraindication

Hypersensitivity or asthma-type reactions to piroxicam, aspirin or other NSAIDs. History or active GI ulceration, bleeding and perforation; history of GI disorders that predispose to bleeding disorders (e.g. ulcerative colitis, Crohn’s disease, GI cancers or diverticulitis). Treatment of perioperative pain in the setting of CABG surgery. Concomitant use with aspirin, other NSAIDs and anticoagulants.

Acute Overdose

Symptoms: Lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding, anaphylactoid reactions. Rarely, HTN, acute renal failure, resp depression and coma.

Management: Symptomatic and supportive treatment. Emesis and/or activated charcoal (60-100 g in adults, 1-2 g/kg in childn) and/or osmotic cathartic may be indicated. If patient is comatose, having seizures or lacks the gag reflex, gastric lavage may be done if an endotracheal tube w/ cuff inflated is in place to prevent aspiration of gastric contents.

Innovators Monograph

You find simplified version here Pirovon Dt

FAQ

What is Pirovon Dt used for?

Pirovon Dt is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis.

How does Pirovon Dt work?

Pirovon Dt works by stopping the body's production of a substance that causes pain, fever, and inflammation.

What are the common side effects of Pirovon Dt?

The common side effects of are include:

  • diarrhea.
  • constipation.
  • gas.
  • headache.
  • dizziness.
  • ringing in the ears.

Is Pirovon Dt a painkiller?

Pirovon Dt is a nonsteroidal anti-inflammatory drug used for the treatment of osteoarthritis and rheumatoid arthritis pain and inflammation.

When should be taken of Pirovon Dt?

Pirovon Dt is usually taken once or twice a day. Take Pirovon Dt at around the same time every day.

Is Pirovon Dt safe during pregnancy?

Pirovon Dt capsules are not recommended for use in pregnant women since safety has not been established in humans.Pirovon Dt should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

Is Pirovon Dt safe during breastfeeding?

Pirovon Dt passes through breast milk and may cause side effects in a child who is breastfed. It's not recommended to breastfeed while taking this medication.

Can I drink alcohol with Pirovon Dt?

Avoid drinking alcohol. It may increase your risk of stomach bleeding. Avoid taking aspirin while you are taking Pirovon Dt.

Can I drive after taking Pirovon Dt?

Pirovon Dt may cause drowsiness, dizziness, tiredness, and vision disturbances, do not drive or operate heavy machinery if you feel dizzy.

How long does Pirovon Dt take to work?

Pirovon Dt usually begins to work within 1 week, but in severe cases up to two weeks or even longer may pass before you begin to feel better.

Can I take Pirovon Dt at night?

Pirovon Dt was equally effective when administered in the morning or at night, evidence for the view that a single daily dose relieves symptoms for at least 24 hours.

Is Pirovon Dt a muscle relaxant?

Pirovon Dt helps relieve pain and swelling of various joints and muscles. 

Can I take Pirovon Dt on an empty stomach?

You do not need to take Pirovon Dt with food. However, if you experience some stomach upset, Pirovon Dt can be taken with food. Ask your doctor or pharmacist if you have any other concerns about your diet and this medicine.

How quickly does Pirovon Dt work?

Pirovon Dt usually begins to work within 1 week, but in severe cases up to two weeks or even longer may pass before you begin to feel better.

Is Pirovon Dt good for back pain?

Pirovon Dt can provide effective relief of acute low-back pain with good toleration; it should be considered for use in the initial treatment of this condition.

Does Pirovon Dt cause weight gain?

Pirovon Dt can causes weight gain also with other side effects.

Can I take Pirovon Dt for a long time?

Pirovon Dt usually begins to work within 1 week, but in severe cases up to two weeks or even longer may pass before you begin to feel better.

Who should not take?

Pirovon Dt can increase your risk of fatal heart attack or stroke. Do not use Pirovon Dt just before or after heart bypass surgery . Pirovon Dt may also cause stomach or intestinal bleeding, which can be fatal.

What happens if I miss a dose?

Take Pirovon Dt as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose on Pirovon Dt?

Seek emergency medical attention.Overdose symptoms may include nausea, vomiting, stomach pain, black or bloody stools, or coughing up blood.

*** Taking medicines without doctor's advice can cause long-term problems.
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