Placidyl
Placidyl Uses, Dosage, Side Effects, Food Interaction and all others data.
Placidyl is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists.
Placidyl is a sedative drug and schedule IV (USA) controlled substance. It produces cerebral depression, however the exact mechanism of action is not known.
| Trade Name | Placidyl |
| Availability | Discontinued |
| Generic | Ethchlorvynol |
| Ethchlorvynol Other Names | etclorvinol, Ethchlorvynol |
| Related Drugs | amitriptyline, lorazepam, melatonin, zolpidem, diphenhydramine, Ativan |
| Type | Oral |
| Formula | C7H9ClO |
| Weight | Average: 144.6 Monoisotopic: 144.0341926 |
| Protein binding | 35-50% |
| Groups | Approved, Illicit, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Placidyl is a sedative hypnotic agent used for the short-term management of insomnia.
Used for short-term hypnotic therapy in the management of insomnia for periods of up to one week in duration; however, this medication generally has been replaced by other sedative-hypnotic agents.
How Placidyl works
Although the exact mechanism of action is unknown, ethchlorvynol appears to depress the central nervous system in a manner similar to that of barbiturates. Barbiturates bind at a distinct binding sites associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Toxicity
Symptoms of overdose include thrombocytopenia.
Food Interaction
- Avoid alcohol.
- Take with food. Food reduces irritation.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Placidyl Drug Interaction
Moderate: contained in alcoholic beverages , contained in alcoholic beverages , diphenhydramine, diphenhydramine, duloxetine, duloxetineUnknown: naproxen, naproxen, fexofenadine, fexofenadine, zolpidem, zolpidem, mesalamine, mesalamine, aspirin, aspirin, immune globulin intramuscular, immune globulin intramuscular, acetaminophen, acetaminophen
Placidyl Disease Interaction
Major: alcohol intox, depression, drug dependence, porphyria, renal/liver diseaseModerate: glaucoma, liver disease, resp depression
Elimination Route
Rapidly absorbed from gastrointestinal tract.
Half Life
Plasma half-life is approximately 10 to 20 hours, terminal half-life is 21-100 hours.
Innovators Monograph
You find simplified version here Placidyl
