Plasmodin

Plasmodin Uses, Dosage, Side Effects, Food Interaction and all others data.

A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.

Plasmodin helps inhibit the enzyme dihydropteroate synthetase which is an enzyme necessary in the conversion of PABA to folic acid. As folic acid is vital to the synthesis, repair, and methylation of DNA which is vital to cell growth in Plasmodium falciparum. With this vital nutrient lacking, the parasite has difficulty in reproducing.

Trade Name Plasmodin
Availability Discontinued
Generic Sulfadoxine
Sulfadoxine Other Names Sulfadoxina, Sulfadoxine, Sulfadoxinum, Sulforthomidine, Sulphadoxine, Sulphormethoxine
Type Caplet
Formula C12H14N4O4S
Weight Average: 310.329
Monoisotopic: 310.073575646
Groups Approved, Investigational
Therapeutic Class
Manufacturer Ifars
Available Country Indonesia
Last Updated: September 19, 2023 at 7:00 am
Plasmodin
Plasmodin

Uses

Plasmodin is a long acting sulfonamide used for the treatment or prevention of malaria.

Plasmodin is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well. Plasmodin and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.

Plasmodin is also used to associated treatment for these conditions: Plasmodium Infections

How Plasmodin works

Plasmodin is a sulfa drug, often used in combination with pyrimethamine to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be traveling to, an area where there is a chance of getting malaria. Plasmodin targets Plasmodium dihydropteroate synthase and dihydrofolate reductase. Sulfa drugs or Sulfonamides are antimetabolites. They compete with para-aminobenzoic acid (PABA) for incorporation into folic acid. The action of sulfonamides exploits the difference between mammal cells and other kinds of cells in their folic acid metabolism. All cells require folic acid for growth. Folic acid (as a vitamin) diffuses or is transported into human cells. However, folic acid cannot cross bacterial (and certain protozoan) cell walls by diffusion or active transport. For this reason bacteria must synthesize folic acid from p-aminobenzoic acid.

Food Interaction

  • Take after a meal. Taking sulfadoxine with food, may reduce gastrointestinal irritation.
  • Take with a full glass of water.

Innovators Monograph

You find simplified version here Plasmodin

*** Taking medicines without doctor's advice can cause long-term problems.
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