Pleconaril
Pleconaril Uses, Dosage, Side Effects, Food Interaction and all others data.
Pleconaril is an antiviral drug from viral capsid inhibitor class, manufactured by Schering-Plough and intended for the prevention of acute asthma exacerbations and common cold symptoms in asthmatic patients who have had exposure to picornavirus. It acts by inhibiting viral replication. The use of pleconaril has not gained approval by the U.S. Food and Drug Administration (FDA) due to the fact that it has been found to induce CYP3A enzyme activity, therefore increasing the risk for serious drug interactions.
| Trade Name | Pleconaril |
| Generic | Pleconaril |
| Pleconaril Other Names | Pleconaril |
| Type | |
| Formula | C18H18F3N3O3 |
| Weight | Average: 381.349 Monoisotopic: 381.130026072 |
| Protein binding | >99% |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in upper respiratory infection.
How Pleconaril works
Pleconaril binds to a hydrophobic pocket in viral protein 1, the major protein which makes up the capsid (shell) of picornaviruses. This renders the viral capsid rigid and compressed and prevents the uncoating of its RNA. As a result, the virus is stopped from attaching to the host cell and causing infection.
Elimination Route
70% (oral)
Innovators Monograph
You find simplified version here Pleconaril
