Plgrol 3h
Plgrol 3h Uses, Dosage, Side Effects, Food Interaction and all others data.
(Plgrol 3h) is an inhibitor of platelet aggregation. Lopirel (Plgrol 3h) selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.
Plgrol 3h is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. It has a long duration of action as it is taken once daily and a large therapeutic window as it is given in doses of 75-300mg daily.
| Trade Name | Plgrol 3h |
| Availability | Prescription only |
| Generic | Clopidogrel |
| Clopidogrel Other Names | Clopidogrel, Clopidogrelum |
| Related Drugs | aspirin, lisinopril, metoprolol, propranolol, Xarelto, Plavix, Brilinta, enoxaparin, rivaroxaban, pravastatin |
| Weight | 75mg |
| Type | Tablet |
| Formula | C16H16ClNO2S |
| Weight | Average: 321.822 Monoisotopic: 321.059027158 |
| Protein binding | Both the active and inactive metabolites of clopidogrel are 98% protein bound in plasma. Studies in cows show clopidogrel 71-85.5% bound to serum albumin. |
| Groups | Approved |
| Therapeutic Class | Anti-platelet drugs |
| Manufacturer | Hamaz Pharmaceutical (pvt) Ltd, |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
(Plgrol 3h) is used for the reduction of atherosclerotic events (myocardial infarction, ischaemic stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Plgrol 3h is also used to associated treatment for these conditions: Acute Coronary Syndrome (ACS), Acute Myocardial Infarction (AMI), Cardiovascular Events, Atherothrombotic events
How Plgrol 3h works
Plgrol 3h is metabolized to its active form by carboxylesterase-1. The active form is a platelet inhibitor that irreversibly binds to P2Y12 ADP receptors on platelets. This binding prevents ADP binding to P2Y12 receptors, activation of the glycoprotein GPIIb/IIIa complex, and platelet aggregation.
Dosage
Plgrol 3h dosage
The recommended dose of Lopirel (Plgrol 3h) is 75 mg once daily with or without food.
Side Effects
Generally Plgrol 3h is well tolerated. However, a few common side effects i.e. Influenza-like symptoms, headache, upper respiratory tract infection, dizziness, muscle and back pain, and rash may occur.
Toxicity
A single dose of clopidogrel at 1500-2000mg/kg was lethal to mice and rats while 3000mg/kg was lethal to baboons. Symptoms of overdose include vomiting, breathing difficulty, gastrointestinal hemorrhage, and prostration. Plgrol 3h is irreversibly bound to platelets for their lifetime, which is approximately 11 days. Overdoses of clopidogrel can be treated with platelet transfusions to restore clotting ability.
Precaution
As with other anti-platelet agents, Plgrol 3h should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. Plgrol 3h should be discontinued 7 days prior to surgery. Plgrol 3h should be used with caution in hepatically impaired patients who may have bleeding diatheses.
Interaction
Concomitant use of Heparin, Warfarin and NSAIDs with Plgrol 3h should be undertaken with caution. Plgrol 3h potentiate the effect of Aspirin on collagen-induced platelet aggregation. The safety of chronic concomitant administration of Aspirin and Plgrol 3h has not been established.
Food Interaction
- Take with or without food.
Plgrol 3h Drug Interaction
Moderate: aspirin, aspirin, aspirin, aspirin, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acidsUnknown: ubiquinone, ubiquinone, rosuvastatin, rosuvastatin, metoprolol, metoprolol, metoprolol, metoprolol, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol
Plgrol 3h Disease Interaction
Major: bleedingModerate: liver diseaseMinor: renal dysfunction
Volume of Distribution
The apparent volume of distribution of clopidogrel is 39,240±33,520L.
Elimination Route
A 75mg oral dose of clopidogrel is 50% absorbed from the intestine. Plgrol 3h can be taken with or without food. A meal decreases the AUC of the active metabolite by 57%. The active metabolite of clopidogrel reaches a maximum concentration after 30-60 minutes. Plgrol 3h reached a Cmax of 2.04±2.0ng/mL in 1.40±1.07h.
The AUC for a 300mg oral dose of clopidogrel was 45.1±16.2ng*h/mL for poor metabolizers, 65.6±19.1ng*h/mL for intermediate metabolizers, and 104.3±57.3ng*h/mL for extensive metabolizers. The Cmax was 31.3±13ng/mL for poor metabolizers, 43.9±14ng/mL for intermediate metabolizers, and 60.8±34.3ng/mL for extensive metabolizers.
Half Life
That half life of clopidogrel is approximately 6 hours following a 75mg oral dose while the half life of the active metabolite is approximately 30 minutes.
Clearance
The clearance of a 75mg oral dose was 18,960±15,890L/h and for a 300mg oral dose was 16,980±10,410L/h.
Elimination Route
An oral dose of radiolabelled clopidogrel is excreted 50% in the urine and 46% in the feces over 5 days. The remainder of clopidogrel is irreversibly bound to platelets for their lifetime, or approximately 8-11 days.
Pregnancy & Breastfeeding use
Pregnancy: There are no adequate and well-controlled studies of Plgrol 3h in pregnant women. However, Plgrol 3h should be used during pregnancy only if clearly needed.
Lactation: Plgrol 3h is not recommended for use while breast-feeding. It is not known for sure whether Plgrol 3h is excreted in breast milk, although it is suspected that it is.
Contraindication
Plgrol 3h is contraindicated in patients with a hypersensitivity to the drug substance or any component of the product, and those with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.
Special Warning
Use in children: Safety and effectiveness of Plgrol 3h in pediatric population have not been established.
Acute Overdose
In the event of over dosage no adverse effects were reported and no therapy was substituted.
Symptoms: Prolonged bleeding time and subsequent bleeding complications.
Management: May restore clotting ability with platelet transfusion.
Storage Condition
Store at 25° C.
Innovators Monograph
You find simplified version here Plgrol 3h
Plgrol 3h contains Clopidogrel see full prescribing information from innovator Plgrol 3h Monograph, Plgrol 3h MSDS, Plgrol 3h FDA label
FAQ
What is Plgrol 3h used for?
Plgrol 3h is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent. It prevents platelets from sticking together and forming a dangerous blood clot. Taking Plgrol 3h helps prevent blood clots if you have an increased risk of having them.
How safe is Plgrol 3h?
Plgrol 3h is generally safe to take for a long time. In fact, it works best if you take it for many months or even years. If you're at risk of getting a stomach ulcer, your doctor may prescribe a medicine to help protect your stomach while you're taking Plgrol 3h.
how does Plgrol 3h work?
Plgrol 3h slows the blood's clotting action by making platelets less sticky. Platelets are blood cells that stick together to block cuts and breaks in blood vessels. But if you're at risk of heart attack or stroke, platelets can stick together inside already narrowed blood vessels to form a clot.
What are the common side effects of Plgrol 3h?
Common side effects of Plgrol 3h are include:
- excessive tiredness.
- headache.
- dizziness.
- nausea.
- vomiting.
- stomach pain.
- diarrhea.
- nosebleed.
Is Plgrol 3h safe during pregnancy?
Plgrol 3h can be used throughout pregnancy. There may be another issue related to delivery, however. The patient in question is planning to have a repeat cesarean, and there is some evidence that Plgrol 3h may cause more hemorrhagic complications of surgery.
Is Plgrol 3h safe during breastfeeding?
The manufacturer reports that no adverse effects have been observed in breastfed infants with maternal Plgrol 3h use during lactation in a small number of postmarketing cases.
Can I drink alcohol with Plgrol 3h?
You can drink alcohol with Plgrol 3h. But do not drink too much while taking this medicine.
When should be taken of Plgrol 3h?
It is usually taken once a day with or without food. Take Plgrol 3h at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Can I take Plgrol 3h on an empty stomach?
You can be taken with or without food.
How long does Plgrol 3h take to work?
Plgrol 3h works within 2 hours of taking it.
How is Plgrol 3h eliminated from the body?
An oral dose of radiolabelled Plgrol 3h is excreted 50% in the urine and 46% in the feces over 5 days. The remainder of Plgrol 3h is irreversibly bound to platelets for their lifetime, or approximately 8-11 days.
Is it safe to take Plgrol 3h every other day?
Long term dual anti-platelet therapy with aspirin 81 mg daily and Plgrol 3h 75 mg every other day beyond 12 months after PCI with DES may be a safe and efficacious cost-saving strategy to prevent VLST.
What is Plgrol 3h half-life?
Oral dose of 75 mg, Plgrol 3h has a half-life of approximately 6 hours.
Can I take Plgrol 3h for a long time?
Plgrol 3h oral tablet is used for long-term treatment. It comes with serious risks if you don't take it as prescribed. If you stop taking the drug or don't take it at all: You increase your risk of heart attack or stroke. These conditions can be fatal.
Who should not take Plgrol 3h?
You should not use Plgrol 3h if you have any active bleeding such as a stomach ulcer or bleeding in the brain.Plgrol 3h increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop, if you have blood in your urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds.
What happens if I miss a dose?
Take Plgrol 3h as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention.Overdose can cause excessive bleeding.
Can Plgrol 3h cause heart attacks?
Plgrol 3h may be at increased risk of serious problems like heart attacks or strokes.
Does Plgrol 3h affect the kidneys?
In summary, among patients hospitalized with ACS and treated with Plgrol 3h, lower levels of kidney function were associated with a greater risk of death, hospitalization for AMI, and major bleeding.
Does Plgrol 3h affect sleep?
Plgrol 3h are among the most prescribed drugs in cardiology and are not cited as causing insomnia or sleepiness.
Does Plgrol 3h affect the liver?
Liver damage is a rare side effect of Plgrol 3h.
Does Plgrol 3h weaken immune system?
Plgrol 3h may also cause weak immunosuppression that might contribute to risk of fatal infections.
