PMS-Chloral Hydrate
PMS-Chloral Hydrate Uses, Dosage, Side Effects, Food Interaction and all others data.
A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.
| Trade Name | PMS-Chloral Hydrate |
| Generic | Chloral hydrate |
| Chloral hydrate Other Names | Chloral hydrate, chloral monohydrate, Chloralhydrat, Trichloracetaldehyd-hydrat, trichloroacetaldehyde hydrate |
| Type | |
| Formula | C2H3Cl3O2 |
| Weight | Average: 165.403 Monoisotopic: 163.919862461 |
| Groups | Approved, Illicit, Investigational, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Canada, United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
PMS-Chloral Hydrate is a mild hypnotic used for experimental purposes that was previously used for the treatment of insomnia.
Mainly used as a hypnotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.
PMS-Chloral Hydrate is also used to associated treatment for these conditions: Alcohol Withdrawal Syndrome, Opiate withdrawal symptoms, Postoperative pain, Barbiturate withdrawal, Sedative therapy
Food Interaction
- Avoid alcohol. Ingesting alcohol may cause a disulfiram-like-reaction (flushing, dizziness, tachycardia).
- Take after a meal. If chloral hydrate is being used for sedation, it should be taken after meals. Otherwise, it can be taken with or without food.
Elimination Route
Rapidly absorbed in the GI tract following oral or rectal administration. PMS-Chloral Hydrate and its active metabolite, trichloroethanol, have been detected in CSF, umbilical cord blood, fetal blood, and amniotic fluid.
Elimination Route
Trichloroethanol, trichloroethanol glucuronide, and trichloroacetic acid are excreted in the urine. Some trichloroethanol glucuronide may be secreted into bile and excreted in the feces.
Innovators Monograph
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