pms-Methotrimeprazine

pms-Methotrimeprazine Uses, Dosage, Side Effects, Food Interaction and all others data.

A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

pms-Methotrimeprazine is a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

Trade Name pms-Methotrimeprazine
Availability Discontinued
Generic Methotrimeprazine
Methotrimeprazine Other Names 2-Methoxytrimeprazine, Levomepromazina, Levomepromazine, Lévomépromazine, Levomepromazinum, Methotrimeprazine
Type
Formula C19H24N2OS
Weight Average: 328.472
Monoisotopic: 328.16093409
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country Canada, United States
Last Updated: September 19, 2023 at 7:00 am
pms-Methotrimeprazine
pms-Methotrimeprazine

Uses

pms-Methotrimeprazine is a phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.

For the treatment of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.

pms-Methotrimeprazine is also used to associated treatment for these conditions: Amnesia, Anxiety, Bipolar Affective Disorders, Nausea and vomiting, Pain, Cancer, Phantom Limb Pain (PLP), Post-Herpetic Neuralgia (PHN), Schizophrenia, Senile psychosis, Trigeminal Neuralgia (TN), Neurocostal neuralgia, Perioperative analgesia

How pms-Methotrimeprazine works

pms-Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, its binding to 5HT2 receptors may also play a role.

Toxicity

Symptoms of overdose include convulsions, spastic movements, and coma.

Food Interaction

  • Take with food. Food reduces irritation.

pms-Methotrimeprazine Alcohol interaction

[Moderate] GENERALLY AVOID:

Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.

Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.

The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.



Patients should be advised to avoid alcohol during phenothiazine therapy.

pms-Methotrimeprazine Disease Interaction

Major: dementia

Elimination Route

pms-Methotrimeprazine has an incomplete oral bioavailability, because it undergoes considerable first-pass-metabolism in the liver. Oral bioavailability is approximately 50 to 60%.

Half Life

Approximately 20 hours.

Innovators Monograph

You find simplified version here pms-Methotrimeprazine

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http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6838
http://www.hmdb.ca/metabolites/HMDB0015474
http://www.genome.jp/dbget-bin/www_bget?drug:D00403
http://www.genome.jp/dbget-bin/www_bget?cpd:C07192
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=72287
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507223
https://www.chemspider.com/Chemical-Structure.65239.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50418049
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6852
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6838
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1764
https://zinc.docking.org/substances/ZINC000000020246
http://www.pharmgkb.org/drug/PA164743234
https://en.wikipedia.org/wiki/Levomepromazine
*** Taking medicines without doctor's advice can cause long-term problems.
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