Podophyllotoxin
Podophyllotoxin Uses, Dosage, Side Effects, Food Interaction and all others data.
Podophyllotoxin has an antimitotic action and is used mainly as a topical treatment for anogenital warts.
Podophyllotoxin, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podophyllotoxin is used to remove certain types of warts on the outside skin of the genital areas.
| Trade Name | Podophyllotoxin |
| Availability | Prescription only |
| Generic | Podofilox |
| Podofilox Other Names | Podofilox, Podophyllotoxin |
| Related Drugs | imiquimod topical, Aldara, interferon alfa-2b, Condylox, Intron A, Veregen |
| Type | |
| Formula | C22H22O8 |
| Weight | Average: 414.4053 Monoisotopic: 414.13146768 |
| Groups | Approved |
| Therapeutic Class | Anti neoplastic preparations |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the removal of external genital warts located on the penis and vulva
Podophyllotoxin (PPT), also known as podofilox, is a medical cream that is used to treat genital warts and molluscum contagiosum. It is not recommended in HPV infections without external warts. It can be applied either by a healthcare provider or the person themselves.
Podophyllotoxin is also used to associated treatment for these conditions: External Genital Warts, Perianal Warts
How Podophyllotoxin works
The exact mechanism of action is not well understood. It does appear, however, that it and its derivatives may bind and inhibit topoisomerase II during the late S and early G2 stage. The drug may bind and stabilize the temporary break caused by the enzyme. This disrupts the reparation of the break through which the double-stranded DNA passes, and consequently stops DNA unwinding and replication
Dosage
Podophyllotoxin dosage
Apply twice daily, morning and evening (every 12 hours) for three consecutive days followed by four days without treatment. The use of 0.5% Podophyllotoxin Topical Solution is twice a day for three days constitutes a treatment cycle. Treatment cycles should be repeated up to four times until there is no visible wart tissue.
Side Effects
Irritating to the eyes and mucous membranes; GI disturbances; thrombocytopenia, leucopenia; renal failure; hepatotoxicity; CNS effects; EEG changes; peripheral and autonomic neuropathies; local reactions
Precaution
Avoid excessive application. Avoid contact with eyes and inflamed skin. Not to be used on cervical or urethral warts.
Food Interaction
No interactions found.Elimination Route
Topical application of 0.05 mL of 0.5% podofilox solution to external genitalia did not result in detectable serum levels. Applications of 0.1 to 1.5 mL resulted in peak serum levels of 1 to 17 ng/mL one to two hours after application.
Half Life
1.0 to 4.5 hours.
Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Contraindication
Hypersensitivity; pregnancy; lactation; child.
Innovators Monograph
You find simplified version here Podophyllotoxin
Podophyllotoxin contains Podofilox see full prescribing information from innovator Podophyllotoxin Monograph, Podophyllotoxin MSDS, Podophyllotoxin FDA label
