Pola

Pola Uses, Dosage, Side Effects, Food Interaction and all others data.

Pola is an aminoglyoside antibiotic which is the major component of neomycin. Susceptible organisms include many gram-negative bacteria (but not Pseudomonas) and many strains of Staphylococcus. Used topically in the treatment of skin, eye and ear infections often in combination with steroids and other antimicrobials.

Pola is used for the treatment of bacterial eye infections such as conjunctivitis. Pola is an antibiotic. It is not active against fungi, viruses and most kinds of anaerobic bacteria. Pola works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Pola is useful primarily in infections involving aerobic bacteria bacteria.

Pola
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Dosage
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Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
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Trade Name	Pola
Generic	Framycetin
Framycetin Other Names	Fradiomycin B, Framicetina, Framycetin, Framycétine, Framycetinum, Neomycin B
Type
Formula	C₂₃H₄₆N₆O₁₃
Weight	Average: 614.6437 Monoisotopic: 614.312285588
Groups	Approved
Therapeutic Class	Dressing products for wounds/burns/ulcers, Ophthalmic antibacterial drugs
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Abrasion, Bites, Blepharitis, Conjunctivitis, Conjunctivitis, blepharitis and blepharoconjunctivitis, Dermatitis, Eye infections, Lactation, Ocular infections, Posttraumatic or pre- and postoperative otitis externa, Skin infections, Wounds

Pola is also used to associated treatment for these conditions: Acute Crusting Rhinitis, Conjunctivitis, Corneal Abrasions, Infection, Skin Infections, Bacterial, Stye, Ulcerative keratitis, Acute rhino-sinusitis, Bacterial blepharitis, Nasal carriage of staphylococci

How Pola works

Pola binds to specific 30S-subunit proteins and 16S rRNA, four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.