Polidocanol

Polidocanol Uses, Dosage, Side Effects, Food Interaction and all others data.

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena. The formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization (n) of approximately 9 and a mean molecular weight of approximately 600.

Polidocanol has a concentration and volume dependent damaging effect on the blood vessel endothelium.

Polidocanol
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Polidocanol
Availability	Prescription only
Generic	Polidocanol
Polidocanol Other Names	Aethoxy-sklerol, Laureth 9, Laureth-9, Macrogol 9 lauryl ether, Nonaethylene glycol monododecyl ether, Nonaethylene glycol monolauryl ether, PEG-9 lauryl ether, Polidocanol, Polydocanol, Polyoxyl 9 lauryl ether
Related Drugs	Asclera, Sotradecol
Type	Intravenous
Formula	C₃₀H₆₂O₁₀
Weight	Average: 582.8073 Monoisotopic: 582.434298204
Protein binding	Plasma protein binding was not measured.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Polidocanol is a sclerosing agent used for the treatment of uncomplicated spider veins and uncomplicated reticular veins, all less than 3 mm in diameter, in the lower extremity.

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins and uncomplicated reticular veins in the lower extremity.

Polidocanol is also used to associated treatment for these conditions: Pain caused by Teething, Incompetent accessory saphenous veins, Incompetent great saphenous veins, Superficial venous incompetence, Uncomplicated veins 1 to 3 mm in diameter reticular veins, Uncomplicated veins <1 mm in diameter Spider Veins, Varicosities of the great saphenous vein

How Polidocanol works

When administered, polidocanol locally damages blood vessel endothelium. Following the endothelial damage, platelets aggregate at the site and attach to the venous wall eventually resulting in a dense network of platelets, cellular debris, and fibrin that occludes the vessel. Eventually the vessel is replaced by connective fibrous tissue.

Toxicity

Most adverse reactions are related to the intravenous administration such as local irritation, pain, and hematoma. Extravasation can also be an issue.