Polymyxin E
Polymyxin E Uses, Dosage, Side Effects, Food Interaction and all others data.
Polymyxin E sulphate is a cyclopeptide antibiotic belongs to the polymixin therapeutic class and identical to polymixin E. Polymyxin E is used for the prevention and treatment of diseases caused by sensitive bacteria in poultry and large animal. It causes disorganization of bacterial cell membrane with leakage of intracellular materials and thus inhibits bacterial oxidative metabolism. Resistance to colistin is uncommon.
Polymyxin E is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.
| Trade Name | Polymyxin E |
| Generic | Colistin |
| Colistin Other Names | Colimycin, Colistin, Colistina, Colistine, Colistinum, Kolimycin, Polymyxin E |
| Type | |
| Formula | C52H98N16O13 |
| Weight | Average: 1155.455 Monoisotopic: 1154.74992728 |
| Groups | Approved |
| Therapeutic Class | Cyclopeptide Antibiotic |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Salmonellosis.
Polymyxin E is also used to associated treatment for these conditions: Ear infection bacterial, External ear infection NOS
How Polymyxin E works
Polymyxin E is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Polymyxin E is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.
Dosage
Polymyxin E dosage
Broiler, Shonali, Layer and Breeder: 1ml/2-4 liter water for 3-5 days.Cattle, Calf, Goat and sheep: 1ml/40 kg body weight twice daily for 3-5 days.Or as Directed by the registered Veterinarian.
Toxicity
Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.
Precaution
n/a
Food Interaction
No interactions found.Elimination Route
Very poor absorption from gastrointestinal tract.
Half Life
5 hours
Storage Condition
Store below 30 degree centigrade temperature. Protect from light and moisture. Keep out of the reach of children.
Innovators Monograph
You find simplified version here Polymyxin E
