Polyvin
Polyvin Uses, Dosage, Side Effects, Food Interaction and all others data.
Polyvinyl alcohol is a water-soluble synthetic polymer obtained by polymerization of vinyl alcohol. It has varying roles in commercial and industrial applications such as papermaking, textiles, and printing. Polyvinyl alcohol is found in ophthalmic solutions as a lubricant to prevent irritation or to relieve dryness of the eyes .
Temporarily relieves burning and irritation due to dryness of the eye or from exposure to wind or sun.Lubricates the eyes and helps protect against further eye irritation/dryness .
Providone, also known as polyvinylpyrrolidone (PVP) or polyvidone, is a synthetic water-soluble polymer made from the monomer N-vinylpyrrolidone that is used as a binder in many pharmaceutical tablets and lubricant in eye drops. It is also used in many technical applications with various roles as an adhesive, additive, and emulsifier. When in complex with iodine, Povidone-iodine displays antiseptic properties where the iodine, a bactericidal component, mainly contributes to this effect and povidone acts as a carrier . Povidone-iodine can be found in over-the-counter topical solutions, ointment, pessaries, liquid soaps and surgical scrubs. The clinical effectiveness of Povidone-iodine on wound healing remains somewhat controversial, as it was demonstrated in few clinical studies that application of the compound in wounds was associated with impaired wound healing, reduced wound strength, or infection in open wounds .
Povidone itself has no microbicidal activity. Povidone-iodine exhibits rapid, potent, broad-spectrum antimicrobial properties . The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application .
| Trade Name | Polyvin |
| Generic | Povidone + Polyvinyl Alcohol |
| Weight | 0.6%w/v |
| Type | Eye Drops |
| Therapeutic Class | |
| Manufacturer | Optho Remedies Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Polyvinyl alcohol is a compound used as an ophthalmic lubricant.
For use as a lubricant to prevent further irritation or to relieve dryness of the eye(s) .
When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
Polyvin is also used to associated treatment for these conditions: Dry Eyes, Eye lubricationDry Eyes, Skin disinfection
How Polyvin works
As a synthetic resin with hydrophilic properties, it increases the persistence of tear film and therefore lubricates and soothes dry/irritated eyes .
Povidone-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen . Please refer to the drug entry for Povidone-iodine for the full mechanism of action of the complex.
Toxicity
The oral acute toxicity of PVOH (LD50) in rats and mice are 20 g/kg and 14.7 g/kg, respectively . Adverse effects include eye pain and changes of vision, and redness or irritation of the eye .
Mild stinging or irritation of the eye, crusting of eyelid, eye pain, ocular hyperaemia, eye pruritus, foreign body sensation, eye discharge, and increased lacrimation may also occur .
Oral LD50 in mouse, rat, and rabbit are >40 mg/kg, 100 mg/kg, and 1040 mg/kg, respectively . No cases of overdose in humans have been reported.
Volume of Distribution
This drug does not accumulate in the body when administered orally .
This pharmacokinetic data does not apply to povidone.
Elimination Route
Polyvinyl alcohol is poorly absorbed from gastrointestinal tract, and readily eliminated from the body .
This pharmacokinetic data does not apply to povidone.
Half Life
When injected intravenously, polyvinyl alcohol has a half-life of 90 min .
Intraocularly, in eye drop form, the half-life is 7.2 minutes .
This pharmacokinetic data does not apply to povidone.
Clearance
This pharmacokinetic data does not apply to povidone.
Elimination Route
This pharmacokinetic data does not apply to povidone.
Innovators Monograph
You find simplified version here Polyvin
