Povidonum

Povidonum Uses, Dosage, Side Effects, Food Interaction and all others data.

Providone, also known as polyvinylpyrrolidone (PVP) or polyvidone, is a synthetic water-soluble polymer made from the monomer N-vinylpyrrolidone that is used as a binder in many pharmaceutical tablets and lubricant in eye drops. It is also used in many technical applications with various roles as an adhesive, additive, and emulsifier. When in complex with iodine, Povidonum-iodine displays antiseptic properties where the iodine, a bactericidal component, mainly contributes to this effect and povidone acts as a carrier . Povidonum-iodine can be found in over-the-counter topical solutions, ointment, pessaries, liquid soaps and surgical scrubs. The clinical effectiveness of Povidonum-iodine on wound healing remains somewhat controversial, as it was demonstrated in few clinical studies that application of the compound in wounds was associated with impaired wound healing, reduced wound strength, or infection in open wounds .

Povidonum itself has no microbicidal activity. Povidonum-iodine exhibits rapid, potent, broad-spectrum antimicrobial properties . The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application .

Trade Name Povidonum
Availability Rx and/or OTC
Generic Povidone
Povidone Other Names Polividone, Povidona, Povidone, Povidone, unspecified, Povidonum
Related Drugs Betadine, iodine topical, ethanol topical, silver nitrate topical, Dakins Full Strength Solution
Type
Protein binding

This pharmacokinetic data does not apply to povidone.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Povidonum
Povidonum

Uses

When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.

Povidonum is also used to associated treatment for these conditions: Dry Eyes, Skin disinfection

How Povidonum works

Povidonum-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen . Please refer to the drug entry for Povidonum-iodine for the full mechanism of action of the complex.

Toxicity

Oral LD50 in mouse, rat, and rabbit are >40 mg/kg, 100 mg/kg, and 1040 mg/kg, respectively . No cases of overdose in humans have been reported.

Food Interaction

No interactions found.

Povidonum Disease Interaction

Moderate: thyroid/metabolic abnormality

Volume of Distribution

This pharmacokinetic data does not apply to povidone.

Elimination Route

This pharmacokinetic data does not apply to povidone.

Half Life

This pharmacokinetic data does not apply to povidone.

Clearance

This pharmacokinetic data does not apply to povidone.

Elimination Route

This pharmacokinetic data does not apply to povidone.

Innovators Monograph

You find simplified version here Povidonum

*** Taking medicines without doctor's advice can cause long-term problems.
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