Powersol IV Infusion 5%

Powersol IV Infusion 5% Uses, Dosage, Side Effects, Food Interaction and all others data.

Each 100 ml solution (5%) contains:Essential Amino Acids- L-Isoleucine 0.352 gm L-Leucine 0.490 gm L-Lysine Hydrochloride 0.430 gm L-Methionine 0.225 gm L-Phenylalanine 0.533 gm L-Threonine 0.250 gm L-Tryptophan 0.090 gm L-Valine 0.360 gm L-Histidine 0.250 gm L-Tyrosine 0.025 gm Non Essential Amino Acids- L-Arginine 0.500 gm L-Aspartic Acid 0.250 gm L-Glutamic Acid 0.075 gm L-Alanine 0.200 gm L-Cystine 0.010 gm Glycine (Aminoacetic Acid) 0.760 gm L-Proline 0.100 gm L-Serine 0.100 gm Excipients D-Sorbitol 5.000 gm Electrolytes Sodium (Na+) 57 mmol/L Potassium (K+) 25 mmol/L Magnesium (Mg++) 1.2 mmol/L Chloride (Cl-) 87 mmol/L Acetate (CH3COO-) 25 mmol/L Total Nitrogen Content: 7.25 gm/LTotal Energy Content: 1551 kj/L (371.14 Kcal/L)

Powersol IV Infusion 5%
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Powersol IV Infusion 5%
Generic	Amino Acid, D-Sorbitol with Electrolytes
Weight	5%
Type	IV Infusion
Therapeutic Class	Parenteral nutritional preparations
Manufacturer	General Pharmaceuticals Ltd.
Available Country	Bangladesh
Last Updated:	October 19, 2023 at 6:27 am

Uses

Amino acid is indicated as a source of amino acids for protein synthesis in patients needing intravenous nutrition. Amino acid is particularly suitable for patients with basal amino acid requirements. Amino acid is also indicated in faster recovery in surgery, burns, renal insufficiency, hepatic insufficiency and effective management of cancer.

Dosage

Powersol IV Infusion 5% dosage

The nitrogen requirement for maintenance of body protein mass depends on the patient's condition (nutritional state and degree of metabolic stress). No or minor metabolic stress and normal nutritional state: 0.10-0.15 g nitrogen/kg/day, Moderate metabolic stress with or without malnutrition: 0.15-0.20 g nitrogen/kg/day, Severe catabolism as in burns, sepsis and trauma: up to 0.20-0.25 g nitrogen/kg/day. The dosage range 0.10-0.25 g nitrogen/kg/day corresponds to 15-35 ml Amino acidsIV/kg/day.In obese patients, the dose should be based on the estimated ideal weight. Depending upon patients requirements, 1000-2000 ml Amino acids IV may be infused intravenously per 24 hours. Amino acids IV should be infused slowly, at rates 1.4-2.8 ml (30-60 drops) per minute.In children and infants: The rate of infusion is 28-35 ml/kg body weight per day is recommended, with a step-wise increase in the rate of administration during the frst week.

Side Effects

This preparation is usually well tolerated. Nausea occurs rarely. Vomiting, flushing and sweating have been observed during infusion of Amino acid at rates exceeding the recommended maximal rate. Transient increases liver test during intravenous nutrition have been reported. The reasons are at present unclear. Hypersensitivity reactions have been reported. As with all hypertonic infusion solutions, thrombophlebitis may occur when peripheral veins are used. The incidence may be reduced by the simultaneous infusion of 10% fat emulsion. If given to severely ill, premature infants, hyperphenylalaninemia may occur.

Precaution

IV infusion of amino acids is accompanied by increased urinary excretion of the trace elements copper and in particular zinc, which should be taken into account in the dosing of trace elements, particularly during long-term IV nutrition. Hyperphenylalaninemia may occur in severely ill, premature infants. In these patients, monitoring of the phenylalanine level is recommended and the infusion rate adjusted as needed. Amino Acids IV infusion and 10% Glucose with Electrolytes should be used with caution in patients with diabetes mellitus, severe heart failure or with renal function in combination with fluid restrictions or oliguria/anuria of another origin. In patients with hyperglycemia, administration of exogenous insulin might be necessary. In severely malnourished patients refeeding carbohydrates can trigger thiamine (vitamin B1 ) deficiency syndrome. Those at high risk are patients with a history of alcohol abuse, anorexia nervosa, prolonged fasting or starvation and pregnant women with hyperemesis gravidarum. In this kind of patients, parenteral nutrition containing glucose should be given with caution and parenteral administration of thiamine should be considered before and during the administration of glucose. Monitoring of serum potassium and blood glucose is recommended if Amino Acids IV infusion and 10% Glucose with electrolytes is infused rapidly or in a large quantity. For patients with hypophosphatemia, an additional supply of phosphate is recommended.

Interaction

At the recommended dosage the amino acid have no pharmacological effects and is not expected to interact with other medicaments.

Pregnancy & Breastfeeding use

Successful and safe administration of amino acid solutions during pregnancy in the human has been reported. Animal reproduction studies have not been carried out with Amino acid.

Contraindication

This is contraindicated in patients with inborn errors of amino acids metabolism, severe liver dysfunction and in severe uremia when dialysis facilities are not available. Due to the content of glucose, Amino Acids IV infusion and 10% Glucose with Electrolytes is contraindicated in patients with hyperosmolar nonketotic diabetic coma.

Acute Overdose

If Amino Acids IV infusion and 10% Glucose with Electrolytes is administered at a higher rate than recommended, there is an augmented risk for nausea, vomiting and sweating. When peripheral veins are used thrombophlebitis may occur. Osmotic diuresis with dehydration may occur if the dosage recommendations are exceeded. There is also a risk of symptoms related to hyperglycemia with Amino Acids IV infusion and 10% Glucose with Electrolytes. In case of symptoms due to overdose, the infusion should be slowed down or discontinued.