Prednisolone 21-phosphate

Prednisolone 21-phosphate Uses, Dosage, Side Effects, Food Interaction and all others data.

Prednisolone 21-phosphate is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone 21-phosphate was granted FDA Approval on 19 December 1973.

Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. Prednisolone has a short duration of action as the half life is 2-4 hours. Corticosteroids have a wide therapeutic window as patients make require doses that are multiples of what the body naturally produces. Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.

Prednisolone 21-phosphate
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Prednisolone 21-phosphate
Generic	Prednisolone phosphate
Prednisolone phosphate Other Names	Prednisolone 21-monophosphate, Prednisolone 21-phosphate
Type
Formula	C₂₁H₂₉O₈P
Weight	Average: 440.429 Monoisotopic: 440.160004892
Protein binding	Prednisolone is 70-90% protein bound in plasma. Prednisolone typically binds to albumin and corticosteroid binding globulin.
Groups	Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Prednisolone 21-phosphate is a corticosteroid used to treat inflammation, immune reactions, as well as endocrine or neoplastic conditions.

Prednisolone 21-phosphate is indication to a number of conditions including treat allergic states, dermatologic diseases, edematous states, endocrine disorders, gastrointestinal diseases, hematologic disorders, neoplastic diseases, nervous system, ophthalmic diseases, respiratory diseases, rheumatic disorders.

Prednisolone 21-phosphate is also used to associated treatment for these conditions: Allergic Conditions, Dermatologic Disease, Edema, Endocrine Disorders, Gastrointestinal Diseases, Haematological disorders, Multiple sclerosis exacerbation, Neoplastic Disease, Ocular Inflammation, Ophthalmia, Sympathetic, Respiratory Diseases, Rheumatic disorder, Temporal Arteritis, Uveitis

How Prednisolone 21-phosphate works

The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.

Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10.

Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.

Toxicity

Data regarding acute overdose is not readily available. However, patients experiencing chronic overdose may present with mental symptoms, moon face, abnormal fat deposits, and fluid retention. Acute oral overdose may be treated with immediate gastric lavage or emesis followed by symptomatic and supportive treatment. Chronic overdosage can be managed by temporary dose reduction or alternate day treatment.

Food Interaction

Take with food. Food reduces GI irritation.

Volume of Distribution

The volume of distribution of prednisolone phosphate has been reported as 0.22-0.7L/kg.

Elimination Route

A 30mg prednisolone oral solution reaches a C_max of 461.33±77.94ng/mL with an AUC of 2426.1±360.0ng*h/mL. A 30mg prednisolone orally disintegrating tablet reaches a C_max of 420.91±78.28ng/mL with an AUC of 2408.1±361.5ng*h/mL.