Presamide Uses, Dosage, Side Effects and more
A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
| Trade Name | Presamide |
| Generic | Phenylbutazone + Prednisolone and Prednisone + Sulphacetamide |
| Weight | 0.12%w/v, 0.2%w/v, 1%w/v |
| Type | Eye Drops |
| Therapeutic Class | |
| Manufacturer | Atco Laboratories Limited |
| Available Country | Pakistan |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Phenylbutazone is an NSAID used to treat backache and ankylosing spondylitis.
For the treatment of backache and ankylosing spondylitis
Presamide is also used to associated treatment for these conditions: Inflammation, Pain, Arthritic pain
How Presamide works
Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.
Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
