Prevatec
Prevatec Uses, Dosage, Side Effects, Food Interaction and all others data.
| Trade Name | Prevatec |
| Generic | Exisulind |
| Exisulind Other Names | Exisulind, Sulindac sulfone |
| Type | |
| Formula | C20H17FO4S |
| Weight | Average: 372.41 Monoisotopic: 372.083158364 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in adenomatous polyposis coli, lung cancer, prostate cancer, colon polyps, Barrett's esophagus disease, and pediatric indications.
How Prevatec works
Prevatec is a sulindac derivative of a class of compounds called selective apoptotic anti-neoplastic drugs (SAANDs), which inhibit the enzyme cyclic guanosine monophosphodiesterase (cGMP - PDE). Prevatec is specific for apoptotic effects in precancerous and cancerous colorectal cells due to their overexpression of cGMP. Sustained elevation of cGMP and protein kinase G (PKG) activation may be also implicated in the induction of apoptosis by Prevatec.
Innovators Monograph
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