Previfem 28 Day

Previfem 28 Day Uses, Dosage, Side Effects, Food Interaction and all others data.

Previfem 28 Day was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with ethinylestradiol as a combined oral contraceptive that can also be used to treat moderate acne vulgaris.

Previfem 28 Day was granted FDA approval on 29 December 1989.

Previfem 28 Day is a progestin that suppresses ovulation for contraception and reduces free testosterone to treat moderate acne vulgaris. The therapeutic index is wide as overdoses are rare. Patients should be counselled regarding the risk of vascular problems, liver disease, hypertension, metabolic effects, headaches, and bleeding irregularities.

Previfem 28 Day
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Previfem 28 Day
Generic	Norgestimate
Norgestimate Other Names	Dexnorgestrel Acetime, Norgestimate, Norgestimato, Norgestimatum
Type
Formula	C₂₃H₃₁NO₃
Weight	Average: 369.4971 Monoisotopic: 369.230393863
Protein binding	17-desacetylnorgestimate is 97.2% bound to albumin and Norgestrel is >97% protein bound, including 92.5% bound to sex hormone binding globulin.
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Previfem 28 Day is a progesterone used as a contraceptive and to treat acne vulgaris.

Previfem 28 Day is formulated with ethinylestradiol as a combined oral contraceptive. It can also be given with low dose ethinylestradiol for contraception as well as the treatment of moderate acne vulgaris in women ≥15 years old.

Previfem 28 Day is also used to associated treatment for these conditions: Hypermenorrhea, Idiopathic Hirsutism, Menstrual Distress (Dysmenorrhea), Postmenopausal Osteoporosis, Moderate Acne vulgaris, Moderate Menopausal Vasomotor Symptoms, Moderate Vulvovaginal atrophy, Severe Vasomotor Symptoms Associated With Menopause, Severe menopausal vulvovaginal atrophy, Oral Contraceptives

How Previfem 28 Day works

Progesterone analogs like norgestimate decrease the frequency of gonadotropin releasing hormone pulses from the hypothalamus, decreasing follicle stimulating hormone and luteinizing hormone. These actions prevent ovulation.

Previfem 28 Day suppresses the hypothalamo-pituitary-axis, reducing androgen synthesis. It also induces production of sex hormone binding globulin, which decreases free testosterone. These actions together result in less testosterone being available to stimulate sebaceous glands, resulting in effective treatment of some forms of acne.

Toxicity

Data regarding overdoses of norgestimate are rare. However, the majority of patients overdosing on oral contraceptives do not become seriously ill. Treat overdoses with symptomatic and supportive care.

Food Interaction

Take at the same time every day.
Take with or without food.

Volume of Distribution

Data regarding the volume of distribution of norgestimate are not readily available.

Elimination Route

Oral norgestimate has a T_max of 0.5-2h.

On day 21 of cycle 3, 17-desacetylnorgestimate reaches a C_max of 1.82ng/mL, with a T_max of 1.5h, and an AUC of 16.1h*ng/mL. At the same time, norgestrel reaches a C_max of 2.79ng/mL, with a T_max of 1.7h, and an AUC of 49.9h*ng/mL.

Half Life

Previfem 28 Day is rapidly deacetylated. The active metabolites of norgestimate, 17-desacetyl norgestimate, has a half life of 12-30h, while norgestrel has a half life of 36.4±10.2h.